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However, the relation of &lt;i&gt;in vivo&lt;\/i&gt;platelet activation and adverse clinical events to results of platelet function tests remains largely unknown. A valuable marker of &lt;i&gt;in vivo&lt;\/i&gt;platelet activation should be specific, unaltered by pre-analytical artefacts and reproducibly measured by easily performed methods. This article describes current biomarkers of platelet activation in ACS, reviews their advantages and disadvantages, discusses their potential pitfalls, and demonstrates emerging data supporting the positive clinical implications of monitoring in vivo platelet ac- tivation in the setting of ACS.<\/jats:p>","DOI":"10.1160\/th12-08-0550","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T03:39:59Z","timestamp":1348803599000},"page":"1109-1123","source":"Crossref","is-referenced-by-count":82,"title":["Biomarkers of platelet activation in acute coronary syndromes"],"prefix":"10.1160","volume":"108","author":[{"given":"Patrizia","family":"Ferroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Riondino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale","family":"Vazzana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Santoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella","family":"Guadagni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dav\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"10.1160\/TH12-08-0550-1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.2.211"},{"key":"10.1160\/TH12-08-0550-2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022600"},{"key":"10.1160\/TH12-08-0550-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.051"},{"key":"10.1160\/TH12-08-0550-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03584.x"},{"key":"10.1160\/TH12-08-0550-5","doi-asserted-by":"publisher","DOI":"10.1159\/000073571"},{"key":"10.1160\/TH12-08-0550-6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"10.1160\/TH12-08-0550-7","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4324"},{"key":"10.1160\/TH12-08-0550-8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012044"},{"key":"10.1160\/TH12-08-0550-9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27196"},{"key":"10.1160\/TH12-08-0550-10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.150474"},{"key":"10.1160\/TH12-08-0550-11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI973"},{"key":"10.1160\/TH12-08-0550-12","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.1.175"},{"key":"10.1160\/TH12-08-0550-13","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.02.012"},{"key":"10.1160\/TH12-08-0550-14","doi-asserted-by":"crossref","unstructured":"Sedky HA, et al. 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