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It has become increasingly clear that the complement system, part of the innate immune system, has an important role in the pathophysiology of these diseases. Not only does complement influence prothrombotic disease, it is equally involved in idiopathic thrombocytopenic purpura (ITP), an autoimmune disease characterised by thrombocytopenia. Thus, there are complex interrelationships between the haemostatic and immune systems, and platelets and complement in particular. Not only does complement influence platelet diseases such as ITP, HUS and PNH, it also mediates interaction between microbes and platelets during systemic infection, influencing the course of infection and development of protective immunity. This review aims to provide an integrative overview of the mechanisms underlying the interactions between complement and platelets in health and disease.<\/jats:p>","DOI":"10.1160\/th13-02-0102","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T13:57:42Z","timestamp":1378389462000},"page":"910-919","source":"Crossref","is-referenced-by-count":76,"title":["Crosstalk between platelets and the complement system in immune protection and disease"],"prefix":"10.1160","volume":"110","author":[{"given":"Harald 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