{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:47:41Z","timestamp":1769204861970,"version":"3.49.0"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"the Korea Healthcare technology R>D Project, Ministry for Health, Welfare & Family Affairs, South Korea","award":["A120080"],"award-info":[{"award-number":["A120080"]}]},{"name":"the Ministry of Education, Science and Technology","award":["2009-0093821 & NRF-2012R1A1A2007033"],"award-info":[{"award-number":["2009-0093821 & NRF-2012R1A1A2007033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Plasminogen activator inhibitor-1 (PAI-1) is important for maintaining pregnancy. Aberrantly increased PAI-1 levels may contribute to thrombosis and inflammation, leading to pregnancy loss. This study investigated the association of PAI-1 polymorphisms (PAI-1 rs2227631 [-844G&gt;A], rs1799889 [-675 4G\/5G], rs6092 [43G&gt;A], rs2227694 [9785G&gt;A], and rs7242 [11053T&gt;G]) with idiopathic recurrent pregnancy loss (RPL) in Korean women. We screened 308 RPL patients and 227 control participants for five PAI-1 polymorphisms. Genotyping of PAI-1 was performed by polymerase chain reaction-restriction fragment length polymorphism assay. PAI-1 4G4G and -844AA\/ 4G4G\/11053GG genotypes were associated with RPL. PAI-1 -844A\/4G\/43G\/9785G\/11053G haplotype was connected to hypofibrinolytic status (i.e. increased levels of plasma PAI-1, increased numbers of platelets, reduced prothrombin time, and reduced activated partial thromboplastin time). Moreover, PAI-1 11053TG+GG frequency was positively related to plasma homocysteine and urate levels, whereas -844AA frequency was associated with plasma folate concentrations according to ordinal logistic regression analysis. Based on these results, we propose that PAI-1 -844G&gt;A, 4G\/5G, and 11053T&gt;G polymorphisms are markers of RPL.<\/jats:p>","DOI":"10.1160\/th13-03-0242","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T07:18:06Z","timestamp":1375341486000},"page":"742-750","source":"Crossref","is-referenced-by-count":28,"title":["Genetic association of five plasminogen activator inhibitor-1 (PAI-1) polymorphisms and idiopathic recurrent pregnancy loss in Korean women"],"prefix":"10.1160","volume":"110","author":[{"given":"Young Joo","family":"Jeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ran","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Eun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Seul","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyang","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Eun","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyungChul","family":"Rah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hee","family":"Cha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/GRF.0b013e31802f1c28","article-title":"Evaluation and management of recurrent early pregnancy loss","volume":"50","author":"M Stephenson","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0897.1997.tb00277.x","article-title":"Current clinical options for diagnosis and treatment of recurrent spontaneous abortion","volume":"38","author":"CB Coulam","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"63.","DOI":"10.1016\/j.fertnstert.2012.09.023","article-title":"Practice Committee of the American Society for Reproductive Medicine. 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