{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:06:33Z","timestamp":1765609593257},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>It was the purpose of this study to assess the effect of thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI) on reperfusion and clinical outcome in a real-world STEMI population. The decision to use TA (Export catheter, Medtronic) was at the discretion of the treating cardiologist. The primary endpoint was mortality at short (in-hospital) and long term (one year) follow-up. Secondary end points were post-PCI TIMI flow, residual ST deviation and enzymatic infarct size. Cox proportional hazard models (propensity-weighted) and logistic regression analysis were used to adjust for known covariates, associated with mortality. We performed a retrospective analysis of prospectively collected data on 2,552 consecutive PPCI-treated STEMI patients between 2007 and 2010. Use of TA increased from 6.9% in 2007 to 62.2% in 2010 (p&lt;0.001). TA was performed in 899 patients (35.2%). In-hospital and one-year mortality rates were 3.0% and 6.0%, respectively, in the TA group and 3.5% and 7.6% in the no- TA group. After multivariate analysis, TA was not significantly associated with in-hospital mortality (adjusted odds ratio [OR]: 0.70; 95% confidence interval [CI]: 0.33\u20131.49, p=0.36) nor one year mortality (adjusted hazard ratio [HR]: 0.75, 95%CI: 0.47\u20131.20, p=0.23) or cardiac mortality (HR: 0.81; 95%CI: 0.45\u20131.46, p=0.49). After matching on the propensity score, the HR in the TA group for one year mortality was 0.70 (95%CI: 0.41\u20131.20, p=0.19) and for one-year cardiac mortality 0.70 (95%CI: 0.36\u20131.34, p=0.28). In conclusion, no significant relationship of TA with one of the secondary end points was found. The use of TA increased over the last years but clinical outcome was similar in both groups (TA vs no-TA) in this large cohort of real-world, unselected STEMI patients.<\/jats:p>","DOI":"10.1160\/th13-05-0433","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T07:48:41Z","timestamp":1380700121000},"page":"165-171","source":"Crossref","is-referenced-by-count":15,"title":["The effect of thrombus aspiration during primary percutaneous coronary intervention on clinical outcome in daily clinical practice"],"prefix":"10.1160","volume":"111","author":[{"given":"Sinem","family":"Kilic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Paul","family":"Ottervanger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Henk E.","family":"Dambrink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan C. A.","family":"Hoorntje","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra C.","family":"Koopmans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. T. Marcel","family":"Gosselink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Suryapranata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnoud W. J.","family":"van \u2019t Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Zwolle Myocardial Infarction Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1161\/CIRCULATIONAHA.110.002741","article-title":"Intracoronary versus intravenous administartion of abciximab in patients with ST-Segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with thrombus aspiration","volume":"122","author":"YL Gu","year":"2010","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(08)60833-8","article-title":"Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute 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A myocardial contrast echocardiography substudy of the REMEDIA Trial","volume":"48","author":"L Galiuto","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1093\/eurheartj\/ehn421","article-title":"Role of adjunctive thrombectomy and em-bolic protection devices in acute myocardial infarction: a comprehensive meta-analysis of randomized trials","volume":"24","author":"AA Bavry","year":"2008","journal-title":"Eur Heart J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCULATIONAHA.108.780734","article-title":"Presence of older thrombus is an independent predictor of long-term mortality in patients with ST-elevation myocardial infarction treated with thrombus aspiration during primary percutaneous coronary intervention","volume":"118","author":"MCA Kramer","year":"2008","journal-title":"Circulation"},{"key":"ref19","first-page":"376","article-title":"Impact of thrombus aspiration on myocardial tissue reperfusion and left ventricular functional recovery and remodeling after primary angioplasty","volume":"2","author":"F Liistro","year":"2009","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST- segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)","volume":"33","author":"PG Steg","year":"2012","journal-title":"Eur Heart J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4244\/EIJV6I6A129","article-title":"Operator dependence of outcome after primary percutaneous coronary intervention","volume":"6","author":"PJ Vlaar","year":"2011","journal-title":"EuroIntervention"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH13-05-0433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:00:59Z","timestamp":1685534459000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH13-05-0433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":21,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,15]]},"published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1160\/th13-05-0433","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"type":"print","value":"0340-6245"},{"type":"electronic","value":"2567-689X"}],"subject":[],"published":{"date-parts":[[2014]]}}}