{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:16:50Z","timestamp":1789085810537,"version":"build-2803163510"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"Japan Takeda Science Foundation"},{"name":"Ministry of Education, Science, and Technology of Korea"},{"name":"The Scientific Research Fund of the Chinese Ministry of Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"DOI":"10.1160\/th13-10-0889","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T09:23:27Z","timestamp":1392888207000},"page":"216-218","source":"Crossref","is-referenced-by-count":4,"title":["The role of cysteinyl cathepsins in venous disorders"],"prefix":"10.1160","volume":"112","author":[{"given":"Takeshi","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kuzuya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian Wu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/0003319706293115","article-title":"The histopathology of varicose vein disease","volume":"57","author":"P Somers","year":"2006","journal-title":"Angiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jvs.2010.09.018","article-title":"Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava","volume":"53","author":"CS Lim","year":"2011","journal-title":"J Vasc Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jvs.2008.06.056","article-title":"Metalloproteinase expression in venous aneurysms","volume":"48","author":"C Irwin","year":"2008","journal-title":"J Vasc Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1160\/TH11-10-0717","article-title":"Molecular imaging of matrix metalloproteinases in atherosclerotic plaques","volume":"107","author":"S Lenglet","year":"2012","journal-title":"Thromb Haemost"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1258\/phleb.2007.007027","article-title":"Mechanisms of varicose vein formation: valve dysfunction and wall dilation","volume":"23","author":"JD Raffetto","year":"2008","journal-title":"Phlebology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/bjs.6798","article-title":"Pathogenesis of primary varicose veins","volume":"96","author":"CS Lim","year":"2009","journal-title":"Br J Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ydbio.2012.10.032","article-title":"Absence of venous valves in mice lacking Connexin37","volume":"373","author":"SJ Munger","year":"2013","journal-title":"Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ydbio.2011.04.004","article-title":"Conne-xin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax","volume":"354","author":"JD Kanady","year":"2011","journal-title":"Dev Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/HYPERTENSIONAHA.111.180935","article-title":"Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications","volume":"58","author":"XW Cheng","year":"2011","journal-title":"Hypertension"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.111.066712","article-title":"Role for cys-teine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication","volume":"125","author":"XW Cheng","year":"2012","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0002-9440(10)63114-8","article-title":"Increased expression of elastolytic cysteine proteases, ca-thepsins S and K, in the neointima of balloon-injured rat carotid arteries","volume":"164","author":"XW Cheng","year":"2004","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathep-sins: from structure, function and regulation to new frontiers","volume":"1824","author":"V Turk","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref13","first-page":"333","article-title":"Increased levels of ly-sosomal cysteinyl cathepsins in human varicose veins: A histology study","volume":"111","author":"N Xu","year":"2013","journal-title":"Thromb Haemost"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/HYPERTENSIONAHA.113.02141","article-title":"Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice","volume":"63","author":"L Hu","year":"2014","journal-title":"Hypertension"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2353\/ajpath.2008.071126","article-title":"Superox-ide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment","volume":"173","author":"XW Cheng","year":"2008","journal-title":"Am J Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2005.10.063","article-title":"Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with ca-thepsin B","volume":"1066","author":"A Nagai","year":"2005","journal-title":"Brain Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19140","DOI":"10.1074\/jbc.M802513200","article-title":"Cys-teine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues","volume":"283","author":"G Droga-Mazovec","year":"2008","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"28858","DOI":"10.1074\/jbc.M111.273292","article-title":"Peroxisome proliferator-activated receptor gamma induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: potential role in atherosclerosis","volume":"286","author":"DF Mahmood","year":"2012","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"F1725","DOI":"10.1152\/ajprenal.90420.2008","article-title":"Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1","volume":"295","author":"NI Alcalay","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00109-008-0423-2","article-title":"Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT\/GSK3beta signaling","volume":"87","author":"Q Tang","year":"2009","journal-title":"J Mol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e13973.","DOI":"10.1371\/journal.pone.0013973","article-title":"Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice","volume":"05","author":"W Yu","year":"2010","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nm1182","article-title":"Cathepsin L is required for endothelial progenitor cell-induced neovascularization","volume":"11","author":"C Urbich","year":"2005","journal-title":"Nat Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2013.01.004","article-title":"Circulating cathepsin K as a potential novel biomarker of coronary artery disease","volume":"228","author":"XW Cheng","year":"2013","journal-title":"Atherosclerosis"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH13-10-0889.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:17:51Z","timestamp":1685535471000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH13-10-0889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":23,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2017,12,1]]},"published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1160\/th13-10-0889","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}