{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:47:08Z","timestamp":1789757228252,"version":"4.0.1"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The post thrombotic syndrome (PTS) develops in 20\u201340% of deep venous thrombosis (DVT) patients. Risk factors for PTS have not been well elucidated. Identification of risk factors would facilitate individualised risk assessment for PTS. We conducted a systematic review to determine whether biomarkers of fibrinolysis or endothelial dysfunction can predict the risk for PTS among DVT patients. Studies were identified by searching the electronic databases PubMed, EMBASE, Scopus and Web of science. We included studies published between 1990 and 2013, measured biomarker levels in adult DVT patients, and reported rates of PTS development. Fourteen studies were included: 11 investigated the association between D-dimer and PTS; three examined fibrinogen; two measured von Willebrand factor; one measured plasminogen activator inhibitor-1; one assessed ADAMTS-13 (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats) and one measured factor XIII activity. Studies varied with regards to inclusion criteria, definition of PTS, time point and method of biomarker measurement. We were unable to meta-analyse results due to marked clinical heterogeneity. Descriptively, a significant association with PTS was found for D-dimer in four studies and factor XIII in one study. Further prospective research is needed to elucidate whether these markers might be useful to predict PTS development.<\/jats:p>","DOI":"10.1160\/th13-11-0931","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T12:36:24Z","timestamp":1391690184000},"page":"1031-1040","source":"Crossref","is-referenced-by-count":33,"title":["The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome"],"prefix":"10.1160","volume":"111","author":[{"given":"Anat","family":"Rabinovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2141.2006.06200.x","article-title":"The postthrombotic syndrome: progress and pitfalls","volume":"134","author":"SR Kahn","year":"2006","journal-title":"Br J Haematol"},{"key":"ref2","first-page":"83","article-title":"Chronic venous disorders of the leg: epidemiology, outcomes, diagnosis and management - Summary of an evidence-based report of the VEINES task force","volume":"18","author":"X Kurz","year":"1999","journal-title":"Int Angiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"116A","DOI":"10.1016\/j.jvs.2007.02.034","article-title":"Molecular characterization of postthrombotic syndrome","volume":"45","author":"LJ Phillips II","year":"2007","journal-title":"J Vasc Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0741-5214(95)70271-7","article-title":"Relationship between changes in the deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb deep vein thrombosis: a one- to six-year follow-up","volume":"21","author":"BF Johnson","year":"1995","journal-title":"J Vasc Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1067\/mva.2002.122887","article-title":"Regarding \u2018\u2018The development of the postthrombotic syndrome in relationship to venous reflux and calf muscle pump dysfunction at 2 years after the onset of deep vein thrombosis\u2019\u2019 [letter]","volume":"35","author":"S Raju","year":"2002","journal-title":"J Vasc Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1538-7836.2004.01106.x","article-title":"Venous abnormalities and the postthrombotic syndrome","volume":"03","author":"P Prandoni","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1056\/NEJMoa054444","article-title":"D dimer testing to determine the duration of anticoagulation therapy","volume":"355","author":"G Palareti","year":"2006","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-149-7-200810070-00008","article-title":"Systematic review: D-dimer to predict recurrent disease after stopping anticoagulation therapy for unprovoked venous thromboembolism","volume":"149","author":"M Verhovsek","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium, I. 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