{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:53:42Z","timestamp":1786362822832,"version":"build-2736575974"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100022274","name":"Daiichi Sankyo Europe GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Due to improved implementation of guidelines, new scoring approaches to improve risk categorisation, and introduction of novel oral anticoagulants, medical management of patients with atrial fibrillation (AF) is continuously improving. The PREFER in AF registry enrolled 7,243 consecutive patients with ECG-confirmed AF in seven European countries in 2012\u20132013 (mean age: 71.5 \u00b1 10.7 years; 60.1% males; mean CHA2DS\n            2\n          -VASc score: 3.4). While patient characteristics were generally homogeneous across countries, anticoagulation management showed important differences: the proportion of patients taking vitamin K antagonists (VKAs) varied between 86.0% (in France) and 71.4% (in Italy). Warfarin was used predominantly in the UK and Italy (74.9% and 62.0%, respectively), phenprocoumon in Germany (74.1%), acenocoumarol in Spain (67.3%), and fluindione in France (61.8 %). The major sites for international normalised ratio (INR) measurements were biology laboratories in France anticoagulation clinics in Italy, Spain, and the UK, and physicians\u2019 offices or self-measurement in Germany. Temporary VKA discontinuation and bridging with other anticoagulants was frequent (at least once in the previous 12 months for 22.9% of the patients, on average; ranging from 29.7% in Germany to 14.9% in the UK). Time in therapeutic range (TTR), defined as at least two of the last three available INR values between 2.0\u20133.0 prior to enrolment, ranged from 70.3% in Spain to 81.4% in Germany. TTR was constantly overestimated by physicians. While the type and half-lives of VKA as well as the mode of INR surveillance differed, overall quality of anticoagulation management by TTR was relatively homogenous in AF patients across countries.<\/jats:p>","DOI":"10.1160\/th13-12-1007","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T12:47:46Z","timestamp":1395319666000},"page":"833-841","source":"Crossref","is-referenced-by-count":74,"title":["Differences among western European countries in anticoagulation management of atrial fibrillation"],"prefix":"10.1160","volume":"112","author":[{"given":"Bettina","family":"Ammentorp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Darius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caterina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard John","family":"Schilling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Zamorano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Le Heuzey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"ref1","first-page":"e6","article-title":"Heart Disease and Stroke Statistics\u20142013 Update: A Report From the American Heart Association","volume":"127","author":"AS Go","year":"2013","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/europace\/eut048","article-title":"Incidence, prevalence, and antithrombotic management of atrial fibrillation in elderly Germans","volume":"15","author":"C Ohlmeier","year":"2013","journal-title":"Europace"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/STROKEAHA.113.000883","article-title":"Risk of stroke or systemic embolism in atrial fibrillation patients treated with warfarin: a systematic review and meta-analysis","volume":"44","author":"IE Albertsen","year":"2013","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1161\/STROKEAHA.109.549428","article-title":"Current status of stroke risk stratification in patients with atrial fibrillation","volume":"40","author":"RG Hart","year":"2009","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/eurheartj\/ehi505","article-title":"Atrial fibrillation management: a prospective survey in ESC Member Countries: The Euro Heart Survey on Atrial Fibrillation","volume":"26","author":"R Nieuwlaat","year":"2005","journal-title":"Eur Heart J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/europace\/eun369","article-title":"The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management","volume":"11","author":"M Nabauer","year":"2009","journal-title":"Europace"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/eurheartj\/ehq278","article-title":"Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)","volume":"31","author":"AJ Camm","year":"2010","journal-title":"Eur Heart J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1160\/TH13-06-0443","article-title":"Vitamin K antagonists in heart disease: Current status and perspectives (Section III). 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Adherence to guidelines, causes of anticoagulation under-use and its clinical outcomes, based on claims-data of 183,448 patients","volume":"107","author":"T Wilke","year":"2012","journal-title":"Thromb Haemost"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1160\/TH13-07-0556","article-title":"Cessation of oral anticoagulation in relation to mortality and the risk of thrombotic events in patients with atrial fibrillation","volume":"110","author":"P Gallego","year":"2013","journal-title":"Thromb Haemost"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/europace\/eut263","article-title":"Management of atrial fibrillation in seven European countries after the publication of the 2010 ESC guidelines on atrial fibrillation. 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