{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:00:02Z","timestamp":1768032002956,"version":"3.49.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Aspirin and statin therapy are mainstay treatments in patients with coronary artery disease (CAD). The relation between statin therapy, in vivo thromboxane (Tx) generation; a marker of inflammation, and blood thrombogenicity has never been explored. Urinary 11-dehydro (dh) TxB2 was determined in patients with suspected CAD on 325 mg daily aspirin therapy prior to undergoing cardiac catheterisation (n=281). Thrombogenicity was estimated by thrombelastographic measurement of thrombin-induced platelet-fibrin clot strength (TIP-FCS) and lipids\/lipoproteins were determined by vertical density gradient ultracentrifugation\/ELISA. The influence of statin therapy and dose was analysed by the atorvastatin equivalent dose (5\u201310 mg, 20\u201340 mg, or 80 mg daily). Statin therapy (n=186) was associated with a dose-dependent reduction in urinary 11-dh TxB2 (p=0.046) that was independent of LDL and apo B100 levels but was strongly related to TIP-FCS (p=0.006). By multivariate analysis, no statin therapy (n=95) and female gender were independently associated with high urinary 11-dh TxB2 [OR=2.95 (0.1.57\u20135.50, p=0.0007); OR=2.25 (1.24\u20134.05, p=0.007)], respectively. In aspirin-treated patients, statin therapy was independently and inversely associated with inflammation in a dose-dependent manner. Elevated 11-dh TxB2 was associated with a prothrombotic state indicated by high TIP-FCS. Our data suggest that measurement of urinary 11-dTxB2 may be a useful method to optimise statin dosing in order to reduce thrombotic risk.<\/jats:p>","DOI":"10.1160\/th14-01-0094","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T13:09:44Z","timestamp":1398690584000},"page":"323-331","source":"Crossref","is-referenced-by-count":10,"title":["Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin"],"prefix":"10.1160","volume":"112","author":[{"given":"Kevin P.","family":"Bliden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Singla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Gesheff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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S.","family":"Tantry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gurbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"C Baigent","year":"2009","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pcad.2009.05.001","article-title":"Aspirin resistance","volume":"52","author":"US Tantry","year":"2009","journal-title":"Prog Cardiovasc Dis"},{"issue":"S 01","key":"ref4","first-page":"III39","article-title":"Beneficial cardiovascular pleiotropic effects 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