{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:21:13Z","timestamp":1790418073722,"version":"4.1.0"},"reference-count":93,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Several haemostatic factors have been associated with incident arterial cardiovascular disease in prospective studies and meta-analyses. Plasma fibrinogen shows a strong and consistent association with risk; however, this may reflect its inflammatory marker status, and causality remains to be proven. The common haemostatic gene polymorphisms for factor II, factor V and the von Willebrand factor: Factor VIII (non-O blood group) show significant associations with coronary heart disease (CHD) risk, consistent with potential causality. Increased D-dimer and t-PA antigen levels are associated with CHD risk, suggesting roles for coagulation activation and endothelial disturbance. There is little evidence for associations with CVD with other haemostatic factors.<\/jats:p>","DOI":"10.1160\/th14-03-0199","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T04:22:31Z","timestamp":1411014151000},"page":"860-867","source":"Crossref","is-referenced-by-count":52,"title":["The relevance of coagulation in cardiovascular disease: what do the biomarkers tell us?"],"prefix":"10.1160","volume":"112","author":[{"given":"Ann","family":"Rumley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"10.1160\/TH14-03-0199-1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/oxfordjournals.bmb.a071433","volume":"33","author":"Macfarlane","year":"1977","journal-title":"Br Med Bull"},{"key":"10.1160\/TH14-03-0199-2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"10.1160\/TH14-03-0199-3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06021.x"},{"key":"10.1160\/TH14-03-0199-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04882.x"},{"key":"10.1160\/TH14-03-0199-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04772.x"},{"key":"10.1160\/TH14-03-0199-6","doi-asserted-by":"crossref","unstructured":"Jespersen J, Bertina RM, Haverkate F. Laboraory testing in thrombosis - a manual., 2nd edn. Dordrecht: Kluwer Academic Publishers, 1999","DOI":"10.1007\/978-94-011-4722-4"},{"key":"10.1160\/TH14-03-0199-7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055175"},{"key":"10.1160\/TH14-03-0199-8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12389"},{"key":"10.1160\/TH14-03-0199-9","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1055\/s-0037-1616754","volume":"86","author":"Lewis","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-10","unstructured":"Woodward M. Epidemiology. Study Design and Data Analysis (2nd ed.). Boca Raton: Chapman and Hall \/ CRC Press, 1999"},{"key":"10.1160\/TH14-03-0199-11","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1055\/s-0037-1616158","volume":"86","author":"Lowe","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-12","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.199448"},{"key":"10.1160\/TH14-03-0199-13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-7-200810070-00008"},{"key":"10.1160\/TH14-03-0199-14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04735.x"},{"key":"10.1160\/TH14-03-0199-15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107477"},{"key":"10.1160\/TH14-03-0199-16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.482570"},{"key":"10.1160\/TH14-03-0199-17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07778.x"},{"key":"10.1160\/TH14-03-0199-18","first-page":"1799","volume":"294","author":"Fibrinogen","year":"2005","journal-title":"J Am Med Assoc"},{"key":"10.1160\/TH14-03-0199-19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2481"},{"key":"10.1160\/TH14-03-0199-20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl441"},{"key":"10.1160\/TH14-03-0199-21","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm191"},{"key":"10.1160\/TH14-03-0199-22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.18.1477"},{"key":"10.1160\/TH14-03-0199-23","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1699"},{"issue":"Suppl 8","key":"10.1160\/TH14-03-0199-24","first-page":"20","volume":"31","author":"Lowe","year":"2001","journal-title":"Proc Roy Coll Phys Edin"},{"key":"10.1160\/TH14-03-0199-25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69776-6"},{"key":"10.1160\/TH14-03-0199-26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002251"},{"key":"10.1160\/TH14-03-0199-27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316885"},{"key":"10.1160\/TH14-03-0199-28","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12229"},{"key":"10.1160\/TH14-03-0199-29","doi-asserted-by":"crossref","unstructured":"Kaptoge S, Seshasai SR, Gao P, et al. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analyses. Eur Heart J 2013; Epub ahead of print","DOI":"10.1093\/eurheartj\/eht367"},{"key":"10.1160\/TH14-03-0199-30","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.09.030"},{"key":"10.1160\/TH14-03-0199-31","doi-asserted-by":"crossref","unstructured":"Sarwar N, Butterworth AS, Freitag DF, et al.; IL6R Genetics Consotium., Emerging Risk Factors Collaboration. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012; 379: 1205-1213","DOI":"10.1016\/S0140-6736(11)61931-4"},{"key":"10.1160\/TH14-03-0199-32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d548"},{"key":"10.1160\/TH14-03-0199-33","doi-asserted-by":"crossref","unstructured":"Lowe G. Woodward M, Hillis G, et al. Circulating inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes mellitus and cardiovascular disease or risk factors: the ADVANCE Study. Diabetes 2014; 63:","DOI":"10.2337\/db12-1625"},{"key":"10.1160\/TH14-03-0199-34","doi-asserted-by":"publisher","DOI":"10.5551\/jat.3673"},{"key":"10.1160\/TH14-03-0199-35","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-5-200403020-00008"},{"key":"10.1160\/TH14-03-0199-36","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.006"},{"key":"10.1160\/TH14-03-0199-37","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1055\/s-0037-1616136","volume":"86","author":"Emmerich","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-38","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00519-2"},{"key":"10.1160\/TH14-03-0199-39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68263-9"},{"key":"10.1160\/TH14-03-0199-40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.557132"},{"key":"10.1160\/TH14-03-0199-41","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-4-199608150-00002"},{"key":"10.1160\/TH14-03-0199-42","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn331"},{"issue":"Suppl 2","key":"10.1160\/TH14-03-0199-43","first-page":"S38","volume":"129","author":"Ten","year":"2012","journal-title":"Thromb Res"},{"key":"10.1160\/TH14-03-0199-44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009480"},{"key":"10.1160\/TH14-03-0199-45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02330.x"},{"key":"10.1160\/TH14-03-0199-46","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.23.2816"},{"key":"10.1160\/TH14-03-0199-47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.635029"},{"key":"10.1160\/TH14-03-0199-48","doi-asserted-by":"crossref","unstructured":"Zakai NA, Katz R, Jenny NS, et al. Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly; the Cardiovascular Health Study. J Thromb Haemost 2007; 5: 1128-1135","DOI":"10.1111\/j.1538-7836.2007.02528.x"},{"key":"10.1160\/TH14-03-0199-49","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1102"},{"key":"10.1160\/TH14-03-0199-50","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.8.1539"},{"key":"10.1160\/TH14-03-0199-51","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000135995.39488.6c"},{"key":"10.1160\/TH14-03-0199-52","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.7.736"},{"key":"10.1160\/TH14-03-0199-53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02221.x"},{"key":"10.1160\/TH14-03-0199-54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04616.x"},{"key":"10.1160\/TH14-03-0199-55","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000244767.39962.f7"},{"key":"10.1160\/TH14-03-0199-56","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.636373"},{"key":"10.1160\/TH14-03-0199-57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01317.x"},{"key":"10.1160\/TH14-03-0199-58","doi-asserted-by":"crossref","unstructured":"Meade TW, Mellows S, Brozovic M, et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; ii: 533-537","DOI":"10.1016\/S0140-6736(86)90111-X"},{"key":"10.1160\/TH14-03-0199-59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb05079.x"},{"key":"10.1160\/TH14-03-0199-60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09134.x"},{"key":"10.1160\/TH14-03-0199-61","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14021-4"},{"key":"10.1160\/TH14-03-0199-62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03201.x"},{"key":"10.1160\/TH14-03-0199-63","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12194"},{"key":"10.1160\/TH14-03-0199-64","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.094232"},{"key":"10.1160\/TH14-03-0199-65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02818.x"},{"key":"10.1160\/TH14-03-0199-66","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1315758"},{"key":"10.1160\/TH14-03-0199-67","first-page":"49","volume":"40","author":"Dentali","year":"2014","journal-title":"Semin Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-68","doi-asserted-by":"crossref","unstructured":"Van Loon JE, Karousi M, Leebeck FW, et al. Von Willebrand factor plasma levels, genetic variations and coronary heart disease in an older population. J Thromb Haemost 2012: 10: 1262-1269","DOI":"10.1111\/j.1538-7836.2012.04771.x"},{"key":"10.1160\/TH14-03-0199-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04634.x"},{"key":"10.1160\/TH14-03-0199-70","unstructured":"Rumley A, Lowe G, Stott D, et al. Coagulation activation markers are associated with cardiovascular events and death in the elderly at risk: PROSPER study cohort. J Thromb Haemost 2009; Suppl 2: Abstract OC-WE-033"},{"key":"10.1160\/TH14-03-0199-71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00656.x"},{"key":"10.1160\/TH14-03-0199-72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-023697"},{"key":"10.1160\/TH14-03-0199-73","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00190-1"},{"key":"10.1160\/TH14-03-0199-74","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00666-9"},{"key":"10.1160\/TH14-03-0199-75","first-page":"878","volume":"89","author":"Santamaria","year":"2004","journal-title":"Haematologica"},{"key":"10.1160\/TH14-03-0199-76","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000133127.68041.a3"},{"key":"10.1160\/TH14-03-0199-77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.009"},{"key":"10.1160\/TH14-03-0199-78","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1160\/TH06-11-0676","volume":"97","author":"Voko","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-79","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj179"},{"key":"10.1160\/TH14-03-0199-80","first-page":"412","volume":"3","author":"Soare","year":"2010","journal-title":"J Med Life"},{"key":"10.1160\/TH14-03-0199-81","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-922485"},{"key":"10.1160\/TH14-03-0199-82","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-01-0032"},{"key":"10.1160\/TH14-03-0199-83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05222.x"},{"key":"10.1160\/TH14-03-0199-84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02819.x"},{"key":"10.1160\/TH14-03-0199-85","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943738"},{"key":"10.1160\/TH14-03-0199-86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02687.x"},{"key":"10.1160\/TH14-03-0199-87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.11.004"},{"key":"10.1160\/TH14-03-0199-88","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92062-X"},{"key":"10.1160\/TH14-03-0199-89","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1055\/s-0038-1657653","volume":"78","author":"Meade","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-90","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0037-1614066","volume":"84","author":"Lowe","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-03-0199-91","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02728.x"},{"key":"10.1160\/TH14-03-0199-92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03267.x"},{"key":"10.1160\/TH14-03-0199-93","unstructured":"Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a meta-analysis. J Thromb Haemost 2001; 5 (Suppl 2): Abstract AS-TH-033"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/th14-03-0199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:17:04Z","timestamp":1565828224000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/th14-03-0199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":93,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,20]]},"published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1160\/th14-03-0199","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}