{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:15Z","timestamp":1790201835301,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"National Research Scholar"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The risk of venous thromboembolism (VTE) is elevated in the postpartum period. Low-molecular-weight heparin (LMWH) reduces the risk of VTE in many settings but is costly, inconvenient and increases bleeding. Randomised controlled trials (RCT) are required to determine if LMWH prophylaxis provides a clinical benefit in high-risk postpartum women. We sought to determine if a placebo-controlled RCT was feasible. We conducted a multi-national, double-blind pilot RCT in \u201chigh risk\u201d postpartum women comparing 21 days of prophylactic dose LMWH to identical saline placebo injections. The primary pilot outcome was mean number of recruited women per centre per month. The planned primary outcome for the full trial was symptomatic objectively confirmed VTE or asymptomatic proximal deep-vein thrombosis diagnosed by a screening bilateral leg vein ultrasound at day 21. In six centres, a total of 1,346 potentially eligible women were approached to participate; 968 were ineligible, leaving 378 (31.5%) eligible patients. Of these, only 25 (6.6%) were randomised at a rate of 0.7 per centre per month. The primary reasons for declining participation were to avoid study injections and being too overwhelmed to participate in research. None of the participants had a VTE during follow-up. In conclusion, despite an adequate number of eligible participants, our double-blind RCT design was not feasible due to a very low consent rate. Other experimental approaches may be necessary to generate evidence in this important area of research.<\/jats:p>","DOI":"10.1160\/th14-06-0485","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T03:36:41Z","timestamp":1415245001000},"page":"212-216","source":"Crossref","is-referenced-by-count":31,"title":["Low-molecular-weight heparin to prevent postpartum venous thromboembolism"],"prefix":"10.1160","volume":"113","author":[{"given":"Penny","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Kahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra H.","family":"James","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Konkle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Rodger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PROSPER Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"10.1160\/TH14-06-0485-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"10.1160\/TH14-06-0485-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00426-3"},{"key":"10.1160\/TH14-06-0485-3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"10.1160\/TH14-06-0485-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02961.x"},{"key":"10.1160\/TH14-06-0485-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02921.x"},{"key":"10.1160\/TH14-06-0485-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(97)80024-7"},{"key":"10.1160\/TH14-06-0485-7","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6926(02)00097-X"},{"key":"10.1160\/TH14-06-0485-8","first-page":"1134","volume":"108","author":"Lepercq","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"10.1160\/TH14-06-0485-9","doi-asserted-by":"publisher","DOI":"10.1159\/000010216"},{"key":"10.1160\/TH14-06-0485-10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0626"},{"key":"10.1160\/TH14-06-0485-11","first-page":"CD001689","volume":"2","author":"Bain","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1160\/TH14-06-0485-12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.039"},{"key":"10.1160\/TH14-06-0485-13","first-page":"835","volume":"108","author":"Burrows","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"10.1160\/TH14-06-0485-14","doi-asserted-by":"crossref","first-page":"e691S","DOI":"10.1378\/chest.11-2300","volume":"141","author":"Bates","year":"2012","journal-title":"Chest"},{"key":"10.1160\/TH14-06-0485-15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1701-2163(15)30569-7","volume":"36","author":"Chan","year":"2014","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1160\/TH14-06-0485-16","unstructured":"RCOG. Green-top guideline no. 37: reducing the risk of thrombosis and embolism during pregnancy and the puerperium. 1-10-2009"},{"key":"10.1160\/TH14-06-0485-17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"10.1160\/TH14-06-0485-18","doi-asserted-by":"crossref","unstructured":"Rodger MA, Hague WM, Kingdom J, et al. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 2014; Epub ahead of print","DOI":"10.1016\/S0140-6736(14)60793-5"},{"key":"10.1160\/TH14-06-0485-19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04553.x"},{"key":"10.1160\/TH14-06-0485-20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-3"},{"key":"10.1160\/TH14-06-0485-21","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-52"},{"key":"10.1160\/TH14-06-0485-22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04337-3"},{"key":"10.1160\/TH14-06-0485-23","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00251-8"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH14-06-0485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T15:53:30Z","timestamp":1540396410000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH14-06-0485"}},"subtitle":["A pilot randomised placebo-controlled trial"],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":23,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,15]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1160\/th14-06-0485","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}