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In this review, we summarise relevant milestones during the time to overcome these limitations of coronary stents, such as the development of polymer-free drug-eluting stents (DES) to avoid pro-inflammatory response due to the polymer coating or the developement of stents with cell-directing drugs to, simultaneously, improve re-endothelialisation and inhibit ISR amongst other techniques most recently developed, which have not fully entered the clinical stage. Also the novel concept of fully biodegradable DES featured by the lack of a permanent foreign body promises to be a beneficial and applicable tool to restore a natural vessel with maintained vasomotion and to enable optional subsequent surgical revascularisation.<\/jats:p>","DOI":"10.1160\/th14-07-0599","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T07:58:04Z","timestamp":1421913484000},"page":"464-472","source":"Crossref","is-referenced-by-count":18,"title":["Progress in interventional cardiology: challenges for the future"],"prefix":"10.1160","volume":"113","author":[{"given":"Elisa","family":"Liehn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Militaru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakine","family":"Simsekyilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"10.1160\/TH14-07-0599-1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90055-1"},{"key":"10.1160\/TH14-07-0599-2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960150715"},{"key":"10.1160\/TH14-07-0599-3","first-page":"3460","volume":"85","author":"Schlumpf","year":"2004","journal-title":"Schweiz \u00c4rztezeit"},{"key":"10.1160\/TH14-07-0599-4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161201"},{"key":"10.1160\/TH14-07-0599-5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"10.1160\/TH14-07-0599-6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"10.1160\/TH14-07-0599-7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000143135.71440.75"},{"key":"10.1160\/TH14-07-0599-8","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76a.09045"},{"key":"10.1160\/TH14-07-0599-9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392303"},{"key":"10.1160\/TH14-07-0599-10","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050369"},{"key":"10.1160\/TH14-07-0599-11","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91383-6"},{"key":"10.1160\/TH14-07-0599-12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.9.806"},{"key":"10.1160\/TH14-07-0599-13","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.532485"},{"key":"10.1160\/TH14-07-0599-14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.02960.x"},{"key":"10.1160\/TH14-07-0599-15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.791061"},{"key":"10.1160\/TH14-07-0599-16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"10.1160\/TH14-07-0599-17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"10.1160\/TH14-07-0599-18","unstructured":"Windecker S, et al. 2014 ESC\/EACTS Guidelines on myocardial revascularisation: The Task Force on Myocardial Revascularisation of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). 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