{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:02:33Z","timestamp":1789524153733,"version":"build-2803163510"},"reference-count":136,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Absent or severely diminished activity of ADAMTS13 (A Disintegrin And Metalloprotease with a ThromboSpondin type 1 motif, member 13) resulting in the intravascular persistence and accumulation of highly thrombogenic ultra large von Willebrand factor (UL-VWF) multimers is the pathophysiological mechanism underlying thrombotic thrombocytopenic purpura. Reduced VWF-cleaving protease levels, however, are not uniquely restricted to primary thrombotic microangiopathy (TMA), e. g. thrombotic thrombocytopenic purpura, but also occur in other life-threatening thrombocytopenic conditions: severely decreased ADAMTS13 activity is seen in severe sepsis, disseminated intravascular coagulation (DIC) and complicated malarial infection. The clinical relevance of these secondary thrombotic microangiopathies is increasingly recognised, but its therapeutic implications have not yet been determined. The presence of a secondary TMA in certain diseases may define patient groups which possibly could benefit from ADAMTS13 replacement or a VWF-targeting therapy. This short-review focuses on the role of UL-VWF multimers in secondary TMA and discusses the potential of investigational therapies as candidates for the treatment of TTP. In conclusion, prospective clinical trials on the effectiveness of protease replacement in vivo seem reasonable. Carefully selected patients with secondary TMA may benefit from therapies primarily intended for the use in patients with TTP.<\/jats:p>","DOI":"10.1160\/th14-09-0731","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T07:08:27Z","timestamp":1418281707000},"page":"708-718","source":"Crossref","is-referenced-by-count":129,"title":["VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP"],"prefix":"10.1160","volume":"113","author":[{"given":"Michael","family":"Schwameis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sch\u00f6rgenhofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Assinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete M.","family":"Steiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"10.1160\/TH14-09-0731-1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1096\/fasebj.7.2.8440408","volume":"7","author":"RuggeriZM,","year":"1993","journal-title":"FASEB J"},{"key":"10.1160\/TH14-09-0731-2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12008"},{"key":"10.1160\/TH14-09-0731-3","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.3.883"},{"key":"10.1160\/TH14-09-0731-4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112771"},{"key":"10.1160\/TH14-09-0731-5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0107"},{"key":"10.1160\/TH14-09-0731-6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112853"},{"key":"10.1160\/TH14-09-0731-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90157-3"},{"key":"10.1160\/TH14-09-0731-8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01360.x"},{"key":"10.1160\/TH14-09-0731-9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301385200"},{"key":"10.1160\/TH14-09-0731-10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442285"},{"key":"10.1160\/TH14-09-0731-11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801735105"},{"key":"10.1160\/TH14-09-0731-12","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12221"},{"key":"10.1160\/TH14-09-0731-13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392203"},{"key":"10.1160\/TH14-09-0731-14","doi-asserted-by":"publisher","DOI":"10.1038\/35097008"},{"key":"10.1160\/TH14-09-0731-15","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-09-0800"},{"key":"10.1160\/TH14-09-0731-16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1401"},{"key":"10.1160\/TH14-09-0731-17","doi-asserted-by":"publisher","DOI":"10.1023\/B:ABME.0000032458.88212.54"},{"key":"10.1160\/TH14-09-0731-18","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10450"},{"key":"10.1160\/TH14-09-0731-19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01978.x"},{"key":"10.1160\/TH14-09-0731-20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.303016"},{"key":"10.1160\/TH14-09-0731-21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383547"},{"key":"10.1160\/TH14-09-0731-22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059372"},{"key":"10.1160\/TH14-09-0731-23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04674.x"},{"key":"10.1160\/TH14-09-0731-24","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12707"},{"key":"10.1160\/TH14-09-0731-25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250604"},{"key":"10.1160\/TH14-09-0731-26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00390.x"},{"key":"10.1160\/TH14-09-0731-27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380535"},{"key":"10.1160\/TH14-09-0731-28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04224.x"},{"key":"10.1160\/TH14-09-0731-29","doi-asserted-by":"publisher","DOI":"10.1586\/erc.10.154"},{"key":"10.1160\/TH14-09-0731-30","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1376883"},{"key":"10.1160\/TH14-09-0731-31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-399501"},{"key":"10.1160\/TH14-09-0731-32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02554.x"},{"key":"10.1160\/TH14-09-0731-33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02232.x"},{"key":"10.1160\/TH14-09-0731-34","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-08-0520"},{"key":"10.1160\/TH14-09-0731-35","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-01-0027"},{"key":"10.1160\/TH14-09-0731-36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.724864"},{"key":"10.1160\/TH14-09-0731-37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03459.x"},{"key":"10.1160\/TH14-09-0731-38","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-02-0069"},{"key":"10.1160\/TH14-09-0731-39","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23106"},{"key":"10.1160\/TH14-09-0731-40","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-12-0889"},{"key":"10.1160\/TH14-09-0731-41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.237529"},{"key":"10.1160\/TH14-09-0731-42","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9435-y"},{"key":"10.1160\/TH14-09-0731-43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-317859"},{"key":"10.1160\/TH14-09-0731-44","unstructured":"Press-release_Phase-II-results-caplacizumab. ABLYNX\u2019S ANTI-vWF NANOBODY, CAPLACIZUMAB, ACHIEVES CLINICAL PROOF-OF-CONCEPT IN PHASE II TITAN STUDY. 2014; p. 4"},{"key":"10.1160\/TH14-09-0731-45","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80023-1"},{"key":"10.1160\/TH14-09-0731-46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1160\/TH08-12-0825","volume":"102","author":"Matsuyama","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-47","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000365"},{"key":"10.1160\/TH14-09-0731-48","doi-asserted-by":"publisher","DOI":"10.1002\/art.21583"},{"key":"10.1160\/TH14-09-0731-49","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0511"},{"key":"10.1160\/TH14-09-0731-50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1087"},{"key":"10.1160\/TH14-09-0731-51","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1842"},{"key":"10.1160\/TH14-09-0731-52","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10262"},{"key":"10.1160\/TH14-09-0731-53","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.11.020"},{"key":"10.1160\/TH14-09-0731-54","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000284508.05247.B3"},{"key":"10.1160\/TH14-09-0731-55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-260"},{"key":"10.1160\/TH14-09-0731-56","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20114"},{"key":"10.1160\/TH14-09-0731-57","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10963"},{"key":"10.1160\/TH14-09-0731-58","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1182\/blood.V94.1.179.413k18_179_185","volume":"94","author":"van","year":"1999","journal-title":"Blood"},{"key":"10.1160\/TH14-09-0731-59","doi-asserted-by":"publisher","DOI":"10.1177\/0192623313518664"},{"key":"10.1160\/TH14-09-0731-60","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11677"},{"key":"10.1160\/TH14-09-0731-61","doi-asserted-by":"publisher","DOI":"10.2174\/156652410790963367"},{"key":"10.1160\/TH14-09-0731-62","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-508093"},{"key":"10.1160\/TH14-09-0731-63","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1160\/TH08-03-0161","volume":"101","author":"Claus","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-44"},{"key":"10.1160\/TH14-09-0731-65","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-06-0376"},{"key":"10.1160\/TH14-09-0731-66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03313.x"},{"key":"10.1160\/TH14-09-0731-67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02743.x"},{"key":"10.1160\/TH14-09-0731-68","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.10.011"},{"key":"10.1160\/TH14-09-0731-69","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0814"},{"key":"10.1160\/TH14-09-0731-70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04367.x"},{"key":"10.1160\/TH14-09-0731-71","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.01.034"},{"key":"10.1160\/TH14-09-0731-72","first-page":"487","volume":"24","author":"Zheng","year":"2012","journal-title":"Chinese Crit Care Med (Zhongguo weizhongbing jijiuyixue)"},{"key":"10.1160\/TH14-09-0731-73","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.09.011"},{"key":"10.1160\/TH14-09-0731-74","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-0038-1655973","volume":"77","author":"Vischer","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-75","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.2.565"},{"key":"10.1160\/TH14-09-0731-76","doi-asserted-by":"publisher","DOI":"10.1186\/cc13115"},{"key":"10.1160\/TH14-09-0731-77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412197"},{"key":"10.1160\/TH14-09-0731-78","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.11.020"},{"key":"10.1160\/TH14-09-0731-79","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-213967"},{"key":"10.1160\/TH14-09-0731-80","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705871200"},{"key":"10.1160\/TH14-09-0731-81","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-10-7"},{"key":"10.1160\/TH14-09-0731-82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019654"},{"key":"10.1160\/TH14-09-0731-83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.12.1341"},{"key":"10.1160\/TH14-09-0731-84","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4856"},{"key":"10.1160\/TH14-09-0731-85","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/296069"},{"key":"10.1160\/TH14-09-0731-86","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.01.015"},{"key":"10.1160\/TH14-09-0731-87","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.02.010"},{"key":"10.1160\/TH14-09-0731-88","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006727"},{"key":"10.1160\/TH14-09-0731-89","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-90","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182908ea7"},{"key":"10.1160\/TH14-09-0731-91","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1367-2"},{"key":"10.1160\/TH14-09-0731-92","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.09.030"},{"key":"10.1160\/TH14-09-0731-93","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235150"},{"key":"10.1160\/TH14-09-0731-94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06067.x"},{"key":"10.1160\/TH14-09-0731-95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000349"},{"key":"10.1160\/TH14-09-0731-96","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-04-0223"},{"issue":"Suppl 1","key":"10.1160\/TH14-09-0731-97","first-page":"86","volume":"24","author":"Srichaikul","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1160\/TH14-09-0731-98","doi-asserted-by":"publisher","DOI":"10.1086\/519844"},{"key":"10.1160\/TH14-09-0731-99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08399.x"},{"key":"10.1160\/TH14-09-0731-100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4269\/ajtmh.1998.58.122","volume":"58","author":"Fischer","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1160\/TH14-09-0731-101","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-254060"},{"key":"10.1160\/TH14-09-0731-102","doi-asserted-by":"publisher","DOI":"10.1086\/380761"},{"key":"10.1160\/TH14-09-0731-103","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-135822"},{"key":"10.1160\/TH14-09-0731-104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025626"},{"key":"10.1160\/TH14-09-0731-105","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-366"},{"key":"10.1160\/TH14-09-0731-106","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1845"},{"key":"10.1160\/TH14-09-0731-107","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-0037-1615149","volume":"80","author":"DeLa","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-108","doi-asserted-by":"publisher","DOI":"10.1126\/science.107355"},{"key":"10.1160\/TH14-09-0731-109","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-06-0490"},{"key":"10.1160\/TH14-09-0731-110","unstructured":"http:\/\/clinicaltrials.gov\/show\/NCT01585259. Available at: http:\/\/clinicaltrials.gov\/show\/NCT01585259"},{"key":"10.1160\/TH14-09-0731-111","doi-asserted-by":"publisher","DOI":"10.5603\/AIT.2014.0018"},{"key":"10.1160\/TH14-09-0731-112","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21296"},{"key":"10.1160\/TH14-09-0731-113","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20296"},{"key":"10.1160\/TH14-09-0731-114","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-14-24"},{"key":"10.1160\/TH14-09-0731-115","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318186aa49"},{"key":"10.1160\/TH14-09-0731-116","first-page":"1379","volume":"369","author":"Legendre","year":"2013","journal-title":"New Engl J Med"},{"key":"10.1160\/TH14-09-0731-117","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12387"},{"key":"10.1160\/TH14-09-0731-118","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01080.x"},{"key":"10.1160\/TH14-09-0731-119","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-271445"},{"key":"10.1160\/TH14-09-0731-120","doi-asserted-by":"publisher","DOI":"10.1080\/10739680701451516"},{"key":"10.1160\/TH14-09-0731-121","first-page":"632","volume":"46","author":"Garba","year":"2005","journal-title":"Singapore Med J"},{"key":"10.1160\/TH14-09-0731-122","first-page":"137","volume":"295","author":"Roberts","year":"2005","journal-title":"Curr Topics Microbiol Imunol"},{"key":"10.1160\/TH14-09-0731-123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010038"},{"key":"10.1160\/TH14-09-0731-124","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3180305c48"},{"key":"10.1160\/TH14-09-0731-125","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000160948.22407.0d"},{"key":"10.1160\/TH14-09-0731-126","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2096"},{"key":"10.1160\/TH14-09-0731-127","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1160\/TH08-10-0677","volume":"101","author":"Zhou","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-09-0731-128","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90224-4"},{"key":"10.1160\/TH14-09-0731-129","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1101"},{"key":"10.1160\/TH14-09-0731-130","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1616"},{"key":"10.1160\/TH14-09-0731-131","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-06-0447"},{"key":"10.1160\/TH14-09-0731-132","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9805087"},{"key":"10.1160\/TH14-09-0731-133","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.1016\/S0021-9258(18)90698-8","volume":"259","author":"de","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1160\/TH14-09-0731-134","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108432"},{"key":"10.1160\/TH14-09-0731-135","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1182\/blood.V85.11.3164.bloodjournal85113164","volume":"85","author":"Vischer","year":"1995","journal-title":"Blood"},{"key":"10.1160\/TH14-09-0731-136","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1055\/s-0037-1613132","volume":"87","author":"Brown","year":"2002","journal-title":"Thromb Haemost"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH14-09-0731.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T02:15:47Z","timestamp":1650766547000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH14-09-0731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":136,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,11,24]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1160\/th14-09-0731","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}