{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:30:29Z","timestamp":1790652629390,"version":"4.1.0"},"reference-count":91,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Transcatheter aortic valve implantation (TAVI) is an established treatment option for symptomatic patients with severe aortic valvular disease who are not suitable for conventional surgical aortic valve replacement. Despite improving experience and techniques, ischaemic and bleeding complications after TAVI remain prevalent and impair survival in this generally old and comorbid-rich population. Due to changing aetiology of complications over time, antiplatelet and anticoagulant therapy after TAVI should be carefully balanced. Empirically, a dual antiplatelet strategy is generally used after TAVI for patients without an indication for oral anticoagulation (OAC; e. g. atrial fibrillation, mechanical mitral valve prosthesis), including aspirin and a thienopyridine. For patients on OAC, a combination of OAC and aspirin or thienopyridine is generally used. This review shows that current registries are unfit to directly compare antithrombotic regimens. Small exploring studies suggest that additional clopidogrel after TAVI only affects bleeding and not ischemic complications. However, these studies are lack in quality in terms of Cochrane criteria. Currently, three randomised controlled trials are recruiting to gather more knowledge about the effects of clopidogrel after TAVI.<\/jats:p>","DOI":"10.1160\/th14-10-0821","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T05:46:21Z","timestamp":1423115181000},"page":"674-685","source":"Crossref","is-referenced-by-count":30,"title":["Antithrombotic treatment in patients undergoing transcatheter aortic valve implantation (TAVI)"],"prefix":"10.1160","volume":"113","author":[{"given":"Vincent J.","family":"Nijenhuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoual","family":"Bennaghmouch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Peter van","family":"Kuijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"10.1160\/TH14-10-0821-1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"10.1160\/TH14-10-0821-2","unstructured":"Kapadia SR. Five-Year Outcomes of Transcatheter Aortic Valve Replacement (TAVR) in \u201cInoperable\u201d Patients With Severe Aortic Stenosis: The PARTNER Trial. In: On behalf of The PARTNER Trial Investigators. 2014. p. TCT 2014 | September 13, 2014, Washington"},{"key":"10.1160\/TH14-10-0821-3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"10.1160\/TH14-10-0821-4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"10.1160\/TH14-10-0821-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.022"},{"key":"10.1160\/TH14-10-0821-6","doi-asserted-by":"crossref","unstructured":"Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014; Epub ahead of print","DOI":"10.1161\/CIR.0000000000000031"},{"key":"10.1160\/TH14-10-0821-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.001"},{"key":"10.1160\/TH14-10-0821-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.04.015"},{"key":"10.1160\/TH14-10-0821-9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"10.1160\/TH14-10-0821-10","unstructured":"Lip GYH, Windecker S, Huber K, et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and\/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on . Eur Heart J 2014; Epub ahead of print"},{"key":"10.1160\/TH14-10-0821-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.005"},{"key":"10.1160\/TH14-10-0821-12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"10.1160\/TH14-10-0821-13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3316"},{"key":"10.1160\/TH14-10-0821-14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.09.012"},{"key":"10.1160\/TH14-10-0821-15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.049"},{"key":"10.1160\/TH14-10-0821-16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.170"},{"key":"10.1160\/TH14-10-0821-17","first-page":"544","volume":"25","author":"Poliacikova","year":"2013","journal-title":"J Invasive Cardiol"},{"key":"10.1160\/TH14-10-0821-18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.033"},{"key":"10.1160\/TH14-10-0821-19","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20544"},{"key":"10.1160\/TH14-10-0821-20","doi-asserted-by":"crossref","unstructured":"Jilaihawi H, Doctor N, Chakravarty T, et al. Major thrombocytopenia after balloon-expandable transcatheter aortic valve replacement: Prognostic implications and comparison to surgical aortic valve replacement. Catheter Cardiovasc Interv 2014; Epub ahead of print","DOI":"10.1002\/ccd.25430"},{"key":"10.1160\/TH14-10-0821-21","first-page":"580","volume":"33","author":"Mueller","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1160\/TH14-10-0821-22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/386074"},{"key":"10.1160\/TH14-10-0821-23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.01.332"},{"key":"10.1160\/TH14-10-0821-24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.960"},{"key":"10.1160\/TH14-10-0821-25","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0556"},{"key":"10.1160\/TH14-10-0821-26","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0351"},{"key":"10.1160\/TH14-10-0821-27","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.271"},{"key":"10.1160\/TH14-10-0821-28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.115386"},{"key":"10.1160\/TH14-10-0821-29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl488"},{"key":"10.1160\/TH14-10-0821-30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61751-7"},{"key":"10.1160\/TH14-10-0821-31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.54506"},{"key":"10.1160\/TH14-10-0821-32","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I1A12"},{"key":"10.1160\/TH14-10-0821-33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864892"},{"key":"10.1160\/TH14-10-0821-34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.935031"},{"key":"10.1160\/TH14-10-0821-35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.042"},{"key":"10.1160\/TH14-10-0821-36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.016"},{"key":"10.1160\/TH14-10-0821-37","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12275"},{"key":"10.1160\/TH14-10-0821-38","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht316"},{"key":"10.1160\/TH14-10-0821-39","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12096"},{"key":"10.1160\/TH14-10-0821-40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000213"},{"key":"10.1160\/TH14-10-0821-41","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.087"},{"key":"10.1160\/TH14-10-0821-42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.967620"},{"key":"10.1160\/TH14-10-0821-43","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I2A43"},{"key":"10.1160\/TH14-10-0821-44","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq427"},{"key":"10.1160\/TH14-10-0821-45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.01.025"},{"key":"10.1160\/TH14-10-0821-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.08.012"},{"key":"10.1160\/TH14-10-0821-47","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq339"},{"key":"10.1160\/TH14-10-0821-48","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.01.389"},{"key":"10.1160\/TH14-10-0821-49","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25233"},{"key":"10.1160\/TH14-10-0821-50","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(10)70031-2"},{"key":"10.1160\/TH14-10-0821-51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.014"},{"key":"10.1160\/TH14-10-0821-52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.07.003"},{"key":"10.1160\/TH14-10-0821-53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"10.1160\/TH14-10-0821-54","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.049"},{"key":"10.1160\/TH14-10-0821-55","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.034"},{"key":"10.1160\/TH14-10-0821-56","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I1A10"},{"key":"10.1160\/TH14-10-0821-57","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303095"},{"key":"10.1160\/TH14-10-0821-58","doi-asserted-by":"publisher","DOI":"10.1159\/000356940"},{"key":"10.1160\/TH14-10-0821-59","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"10.1160\/TH14-10-0821-60","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-012-0486-5"},{"key":"10.1160\/TH14-10-0821-61","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.09.023"},{"key":"10.1160\/TH14-10-0821-62","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.000084"},{"key":"10.1160\/TH14-10-0821-63","first-page":"18","volume":"54","author":"Spargias","year":"2013","journal-title":"Hell J Cardiol"},{"key":"10.1160\/TH14-10-0821-64","doi-asserted-by":"crossref","unstructured":"Magri CJ, Chieffo A, Durante A, et al. Impact of mean platelet volume on combined safety endpoint and vascular and bleeding complications following percutaneous transfemoral transcatheter aortic valve implantation. Biomed Res Int 2013; 2013","DOI":"10.1155\/2013\/645265"},{"key":"10.1160\/TH14-10-0821-65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.015"},{"key":"10.1160\/TH14-10-0821-66","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1001\/jama.2013.282043","volume":"310","author":"Mack","year":"2013","journal-title":"J Am Med Assoc"},{"key":"10.1160\/TH14-10-0821-67","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.907402"},{"key":"10.1160\/TH14-10-0821-68","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr491"},{"key":"10.1160\/TH14-10-0821-69","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.253773"},{"key":"10.1160\/TH14-10-0821-70","doi-asserted-by":"crossref","unstructured":"Wenaweser P, Stortecky S, Heg D, et al. Short-term clinical outcomes among patients undergoing transcatheter aortic valve implantation in Switzerland: the Swiss TAVI registry. EuroIntervention 2014; : 1-20","DOI":"10.4244\/EIJV10I8A166"},{"key":"10.1160\/TH14-10-0821-71","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.110981"},{"key":"10.1160\/TH14-10-0821-72","unstructured":"Linke A. CLaret Embolic Protection ANd TAVI - Trial (CLEAN-TAVI). p. TCT 2014, Washington"},{"key":"10.1160\/TH14-10-0821-73","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001091"},{"key":"10.1160\/TH14-10-0821-74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06477.x"},{"key":"10.1160\/TH14-10-0821-75","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202277"},{"key":"10.1160\/TH14-10-0821-76","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.855866"},{"key":"10.1160\/TH14-10-0821-77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.040"},{"key":"10.1160\/TH14-10-0821-78","doi-asserted-by":"crossref","unstructured":"Devereaux PJ, Mrkobrada M, Sessler DI, et al. Aspirin in Patients Undergoing Noncardiac Surgery. N Engl J Med 2014; : 140331050018004","DOI":"10.1056\/NEJMoa1401105"},{"key":"10.1160\/TH14-10-0821-79","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25053"},{"key":"10.1160\/TH14-10-0821-80","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.10.034"},{"key":"10.1160\/TH14-10-0821-81","first-page":"B218","volume":"58","author":"Stabile","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1160\/TH14-10-0821-82","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I2A32"},{"key":"10.1160\/TH14-10-0821-83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"10.1160\/TH14-10-0821-84","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-1-201101040-00289"},{"key":"10.1160\/TH14-10-0821-85","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24351"},{"key":"10.1160\/TH14-10-0821-86","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(10)70031-2"},{"key":"10.1160\/TH14-10-0821-87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.063"},{"key":"10.1160\/TH14-10-0821-88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.08.012"},{"key":"10.1160\/TH14-10-0821-89","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.930453"},{"key":"10.1160\/TH14-10-0821-90","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"10.1160\/TH14-10-0821-91","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3283515c0f"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH14-10-0821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T13:12:12Z","timestamp":1566306732000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH14-10-0821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":91,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,11,24]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1160\/th14-10-0821","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725339114.793541315","asserted-by":"object"}]},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}