{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:19:51Z","timestamp":1790428791010,"version":"4.1.0"},"reference-count":127,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Austrian Science Fund","award":["FWF-P24978 and FWFSFB-54"],"award-info":[{"award-number":["FWF-P24978 and FWFSFB-54"]}]},{"DOI":"10.13039\/501100004061","name":"Austrian National Bank","doi-asserted-by":"crossref","award":["15961"],"award-info":[{"award-number":["15961"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Platelets are key players in haemostasis and represent a pivotal link between inflammation, immunity and atherogenesis. Depending on the (patho)physiological environment platelets modulate various leukocyte functions via release of inflammatory mediators and direct cell-cell interactions. Elevated levels of circulating platelet-leukocyte aggregates are found in patients suffering from several thrombotic or inflammatory conditions. Platelet-monocyte and platelet-neutrophil interaction can trigger pro- and anti-inflammatory responses and modulate effector functions of all leukocyte subpopulations. These platelet-mediated immune responses have implications for the progression of cardiovascular diseases and also play a crucial role during infections, cancer, transplantations and other inflammatory diseases of several organs. Antiplatelet therapy including the COX inhibitor aspirin and\/or ADP receptor P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor are the therapy of choice for various cardiovascular complications. Both aspirin and P2Y12 inhibitors attenuate platelet-leukocyte interactions, thereby also modulating immune responses. This may have beneficial effects in some pathological conditions, while it might be detrimental in others. This review aims to summarise the current knowledge on platelet-leukocyte interactions and the impact of aspirin and P2Y12 inhibition on platelet-mediated immune responses and to give an overview on the effects of antiplatelet therapy on platelet-leukocyte interplay in various diseases.<\/jats:p>","DOI":"10.1160\/th14-11-0943","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T11:13:26Z","timestamp":1429787606000},"page":"478-789","source":"Crossref","is-referenced-by-count":141,"title":["Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes"],"prefix":"10.1160","volume":"114","author":[{"given":"Waltraud","family":"Schrottmaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Badrnya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Assinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"10.1160\/TH14-11-0943-1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000252802.25497.b7"},{"key":"10.1160\/TH14-11-0943-2","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0341"},{"key":"10.1160\/TH14-11-0943-3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300512"},{"key":"10.1160\/TH14-11-0943-4","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0209117"},{"key":"10.1160\/TH14-11-0943-5","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1182\/blood.V78.7.1730.1730","volume":"78","author":"Rinder","year":"1991","journal-title":"Blood"},{"key":"10.1160\/TH14-11-0943-6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907615"},{"key":"10.1160\/TH14-11-0943-7","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0708400"},{"key":"10.1160\/TH14-11-0943-8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04235.x"},{"key":"10.1160\/TH14-11-0943-9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-069195"},{"key":"10.1160\/TH14-11-0943-10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1160\/TH08-08-0521","volume":"101","author":"Burnier","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-11-0943-11","doi-asserted-by":"publisher","DOI":"10.1159\/000339857"},{"key":"10.1160\/TH14-11-0943-12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118575"},{"key":"10.1160\/TH14-11-0943-13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1160\/TH09-01-0029","volume":"102","author":"Lievens","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-11-0943-14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.2060"},{"key":"10.1160\/TH14-11-0943-15","first-page":"107","volume":"3","author":"Vasina","year":"2013","journal-title":"Am J Blood Res"},{"key":"10.1160\/TH14-11-0943-16","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302919"},{"key":"10.1160\/TH14-11-0943-17","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210406"},{"key":"10.1160\/TH14-11-0943-18","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7771-2-1"},{"key":"10.1160\/TH14-11-0943-19","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10155"},{"key":"10.1160\/TH14-11-0943-20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0038-1650226","volume":"75","author":"Amirkhosravi","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-11-0943-21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359430"},{"key":"10.1160\/TH14-11-0943-22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01603.x"},{"key":"10.1160\/TH14-11-0943-23","doi-asserted-by":"publisher","DOI":"10.1038\/nm810"},{"key":"10.1160\/TH14-11-0943-24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261206"},{"key":"10.1160\/TH14-11-0943-25","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1182\/blood.V95.4.1158.004k31_1158_1166","volume":"95","author":"Scheuerer","year":"2000","journal-title":"Blood"},{"key":"10.1160\/TH14-11-0943-26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901368"},{"key":"10.1160\/TH14-11-0943-27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199505"},{"key":"10.1160\/TH14-11-0943-28","doi-asserted-by":"crossref","unstructured":"Erbel C, et al. CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7+S100A8+ in vitro and in vivo. Innate Immun 2014; Epub ahead of print","DOI":"10.1177\/1753425914526461"},{"key":"10.1160\/TH14-11-0943-29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6265fje"},{"key":"10.1160\/TH14-11-0943-30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201103"},{"key":"10.1160\/TH14-11-0943-31","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.303113"},{"key":"10.1160\/TH14-11-0943-32","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"10.1160\/TH14-11-0943-33","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.06.001"},{"key":"10.1160\/TH14-11-0943-34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-459636"},{"key":"10.1160\/TH14-11-0943-35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040980"},{"key":"10.1160\/TH14-11-0943-36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1182\/blood.V88.1.146.146","volume":"88","author":"Diacovo","year":"1996","journal-title":"Blood"},{"key":"10.1160\/TH14-11-0943-37","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1995.0025"},{"key":"10.1160\/TH14-11-0943-38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437392"},{"key":"10.1160\/TH14-11-0943-39","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0446-6"},{"key":"10.1160\/TH14-11-0943-40","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181bd95b7"},{"key":"10.1160\/TH14-11-0943-41","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5298"},{"key":"10.1160\/TH14-11-0943-42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04606.x"},{"key":"10.1160\/TH14-11-0943-43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04193.x"},{"key":"10.1160\/TH14-11-0943-44","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283324f97"},{"key":"10.1160\/TH14-11-0943-45","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"10.1160\/TH14-11-0943-46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-496661"},{"key":"10.1160\/TH14-11-0943-47","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5272.252"},{"key":"10.1160\/TH14-11-0943-48","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00177-8"},{"key":"10.1160\/TH14-11-0943-49","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1104669"},{"key":"10.1160\/TH14-11-0943-50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71858"},{"key":"10.1160\/TH14-11-0943-51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03983.x"},{"key":"10.1160\/TH14-11-0943-52","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.141515"},{"key":"10.1160\/TH14-11-0943-53","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.05.006"},{"key":"10.1160\/TH14-11-0943-54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5297"},{"key":"10.1160\/TH14-11-0943-55","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001001"},{"key":"10.1160\/TH14-11-0943-56","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-9-54"},{"key":"10.1160\/TH14-11-0943-57","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3676"},{"key":"10.1160\/TH14-11-0943-58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"10.1160\/TH14-11-0943-59","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12156"},{"key":"10.1160\/TH14-11-0943-60","doi-asserted-by":"publisher","DOI":"10.2741\/1939"},{"key":"10.1160\/TH14-11-0943-61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.079"},{"key":"10.1160\/TH14-11-0943-62","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053559.46158.AD"},{"key":"10.1160\/TH14-11-0943-63","first-page":"487","volume":"67","author":"Miedzobrodzki","year":"2010","journal-title":"Acta Pol Pharm"},{"key":"10.1160\/TH14-11-0943-64","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-03-0206"},{"key":"10.1160\/TH14-11-0943-65","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.08.026"},{"key":"10.1160\/TH14-11-0943-66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507762200"},{"key":"10.1160\/TH14-11-0943-67","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.3.1077"},{"key":"10.1160\/TH14-11-0943-68","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000225288.74170.dc"},{"key":"10.1160\/TH14-11-0943-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.002"},{"key":"10.1160\/TH14-11-0943-70","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1160\/TH05-01-0020","volume":"94","author":"Evangelista","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-11-0943-71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02838.x"},{"key":"10.1160\/TH14-11-0943-72","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2003.13"},{"key":"10.1160\/TH14-11-0943-73","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1160\/TH08-05-0313","volume":"100","author":"Braun","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH14-11-0943-74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"10.1160\/TH14-11-0943-75","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-562876"},{"key":"10.1160\/TH14-11-0943-76","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-012-9303-x"},{"key":"10.1160\/TH14-11-0943-77","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0073-8"},{"key":"10.1160\/TH14-11-0943-78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069093"},{"key":"10.1160\/TH14-11-0943-79","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318221d407"},{"key":"10.1160\/TH14-11-0943-80","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.06.016"},{"key":"10.1160\/TH14-11-0943-81","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803251853"},{"key":"10.1160\/TH14-11-0943-82","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-08-0653"},{"key":"10.1160\/TH14-11-0943-83","doi-asserted-by":"publisher","DOI":"10.1160\/THS10-11-0720"},{"key":"10.1160\/TH14-11-0943-84","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26950"},{"key":"10.1160\/TH14-11-0943-85","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707578"},{"key":"10.1160\/TH14-11-0943-86","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23435"},{"key":"10.1160\/TH14-11-0943-87","doi-asserted-by":"publisher","DOI":"10.1038\/nm1780"},{"key":"10.1160\/TH14-11-0943-88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209182109"},{"key":"10.1160\/TH14-11-0943-89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.040"},{"key":"10.1160\/TH14-11-0943-90","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0119-5"},{"key":"10.1160\/TH14-11-0943-91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00630.x"},{"key":"10.1160\/TH14-11-0943-92","doi-asserted-by":"publisher","DOI":"10.1007\/BF00866739"},{"key":"10.1160\/TH14-11-0943-93","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i12.3180"},{"key":"10.1160\/TH14-11-0943-94","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.027"},{"key":"10.1160\/TH14-11-0943-95","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35874"},{"key":"10.1160\/TH14-11-0943-96","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.96357"},{"key":"10.1160\/TH14-11-0943-97","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-5-201203060-00007"},{"key":"10.1160\/TH14-11-0943-98","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04784.x"},{"key":"10.1160\/TH14-11-0943-99","doi-asserted-by":"publisher","DOI":"10.1080\/09537100802082249"},{"key":"10.1160\/TH14-11-0943-100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.08.019"},{"key":"10.1160\/TH14-11-0943-101","doi-asserted-by":"crossref","unstructured":"Tamagawa-Mineoka R, et al. Platelets play important roles in the late phase of the immediate hypersensitivity reaction. J Allergy Cin Immunol 2009; 123: 581-587, e1-9","DOI":"10.1016\/j.jaci.2008.12.1114"},{"key":"10.1160\/TH14-11-0943-102","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08R32FM"},{"key":"10.1160\/TH14-11-0943-103","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328010bd05"},{"key":"10.1160\/TH14-11-0943-104","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12285"},{"key":"10.1160\/TH14-11-0943-105","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22318.x"},{"key":"10.1160\/TH14-11-0943-106","doi-asserted-by":"crossref","unstructured":"Wu S, et al. Use of Aspirin, Nonsteroidal Anti-inflammatory Drugs, and Aceta-minophen (Paracetamol), and Risk of Psoriasis and Psoriatic Arthritis: A Cohort Study. Acta Derm Venereol 2014; Epub ahead of print","DOI":"10.2340\/00015555-1855"},{"key":"10.1160\/TH14-11-0943-107","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.125194"},{"key":"10.1160\/TH14-11-0943-108","doi-asserted-by":"publisher","DOI":"10.3109\/09537100903165174"},{"key":"10.1160\/TH14-11-0943-109","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03101.x"},{"key":"10.1160\/TH14-11-0943-110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02473.x"},{"key":"10.1160\/TH14-11-0943-111","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3269"},{"key":"10.1160\/TH14-11-0943-112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207314109"},{"key":"10.1160\/TH14-11-0943-113","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303287"},{"key":"10.1160\/TH14-11-0943-114","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00649"},{"key":"10.1160\/TH14-11-0943-115","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31828a292c"},{"key":"10.1160\/TH14-11-0943-116","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-02-0126"},{"key":"10.1160\/TH14-11-0943-117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"10.1160\/TH14-11-0943-118","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1038\/ncomms3657","volume":"4","author":"Xiang","year":"2013","journal-title":"Nature Commun"},{"key":"10.1160\/TH14-11-0943-119","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183752"},{"key":"10.1160\/TH14-11-0943-120","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811209023260"},{"key":"10.1160\/TH14-11-0943-121","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182a384f0"},{"key":"10.1160\/TH14-11-0943-122","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384826"},{"key":"10.1160\/TH14-11-0943-123","first-page":"1295","volume":"59","author":"Nieswandt","year":"1999","journal-title":"Cancer Res"},{"key":"10.1160\/TH14-11-0943-124","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60209-8"},{"key":"10.1160\/TH14-11-0943-125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080780"},{"key":"10.1160\/TH14-11-0943-126","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28947"},{"key":"10.1160\/TH14-11-0943-127","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2013.08.006"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH14-11-0943.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T22:34:59Z","timestamp":1651790099000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH14-11-0943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":127,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2017,11,29]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1160\/th14-11-0943","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}