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Disposition for the acute treatment of VTE is then considered based on published risk scores and the patient's social status, as the first seven days carries the highest risk for VTE recurrence, extension and bleeding due to anticoagulation. Next, a review of: immediate and long-term bleeding risk, comorbidities (i. e. active cancer, renal failure, obesity, thrombophilia), medications, patient preference, VTE location and potential for pregnancy should be undertaken. This will help determine the most suitable anticoagulant for immediate treatment. The non-vitamin K antagonist oral anticoagulants (NOACs), including the factor Xa inhibitors apixaban, edoxaban and rivaroxaban as well as the directthrombin inhibitor dabigatran, are increasing the convenience of and options available for VTE treatment. Current options for immediate treatment include low-molecular-weight heparin (LMWH), unfractionated heparin (UFH), fondaparinux, apixaban, or rivaroxaban. LMWH or UFH may be continued as monotherapy or transitioned to treatment with a VKA, dabigatran or edoxaban. This review describes the upfront treatment of VTE and the evolving role of NOACs in the contemporary management of VTE.<\/jats:p>","DOI":"10.1160\/th14-12-1036","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T05:24:21Z","timestamp":1430976261000},"page":"1193-1202","source":"Crossref","is-referenced-by-count":28,"title":["Acute phase treatment of VTE: Anticoagulation, including non-vitamin K antagonist oral anticoagulants"],"prefix":"10.1160","volume":"113","author":[{"given":"Christopher M.","family":"Hillis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,18]]},"reference":[{"key":"10.1160\/TH14-12-1036-1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140904.52752.0c"},{"key":"10.1160\/TH14-12-1036-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)92299-6"},{"key":"10.1160\/TH14-12-1036-3","doi-asserted-by":"crossref","unstructured":"Tagalakis V, et al. 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