{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:07:58Z","timestamp":1775761678742,"version":"3.50.1"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort study was conducted by analysing data from the National Health Insurance Research Database in Taiwan. We included 6,162 splenic injury patients (3,033 splenectomised and 3,129 nonsplenectomised patients) and 24,648 comparison patients who were selected by frequency match based on sex, age, and the index year during 2000\u20132006. All patients were followed until the occurrence of VTE, 31 December, 2011, death, or withdrawal from the insurance program. The age of patients with splenic injury was 41.93 \u00b1 16.44 years. The incidence rates of VTE were 11.81, 8.46, and 5.21 per 10,000 person-years in the splenic injury patients with splen -ectomy, splenic injury patients without splenectomy, and comparison patients, respectively. Compared with the comparison cohort, splenic injury patients with splenectomy exhibited a 2.21-fold risk of VTE (95 % confidence interval [CI], 1.43\u20133.43), whereas those without splenectomy exhibited a 1.71-fold risk of VTE (95 % CI, 1.05\u20132.80). The overall incidence rate of VTE was 1.97-fold higher in the splenic injury cohort than the comparison cohort (95 % CI, 1.38\u20132.81). Although splenectomy increased the risk of VTE 1.35-fold compared with no splenectomy, the difference was not statistically significant (95 % CI, 0.74\u20132.45). These results may alert physicians and patients to the complications of splenic injury and splenectomy.<\/jats:p>","DOI":"10.1160\/th15-05-0381","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T08:47:55Z","timestamp":1441270075000},"page":"176-183","source":"Crossref","is-referenced-by-count":15,"title":["Risk of venous thromboembolism in patients with splenic injury and splenectomy"],"prefix":"10.1160","volume":"115","author":[{"given":"Jiun-Nong","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Ju","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chia","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Hsu","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsi-Hsun","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"10.1160\/TH15-05-0381-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61493-6"},{"key":"10.1160\/TH15-05-0381-2","first-page":"1033","volume":"59","author":"Oida","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"10.1160\/TH15-05-0381-3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-210112"},{"key":"10.1160\/TH15-05-0381-4","first-page":"1","volume":"13","author":"DeFrances","year":"2007","journal-title":"Vital Health Stat"},{"key":"10.1160\/TH15-05-0381-5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/000313480006600511","volume":"66","author":"Rose","year":"2000","journal-title":"Am Surg"},{"key":"10.1160\/TH15-05-0381-6","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31826061fc"},{"key":"10.1160\/TH15-05-0381-7","first-page":"464","volume":"51","author":"Raikhlin","year":"2008","journal-title":"Can J Surg"},{"key":"10.1160\/TH15-05-0381-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2014.06.034"},{"key":"10.1160\/TH15-05-0381-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.11.019"},{"key":"10.1160\/TH15-05-0381-10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000078469.07362.E6"},{"key":"10.1160\/TH15-05-0381-11","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.092460"},{"key":"10.1160\/TH15-05-0381-12","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800681205"},{"key":"10.1160\/TH15-05-0381-13","doi-asserted-by":"publisher","DOI":"10.1159\/000040814"},{"key":"10.1160\/TH15-05-0381-14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03024.x"},{"key":"10.1160\/TH15-05-0381-15","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0904"},{"key":"10.1160\/TH15-05-0381-16","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.7.663"},{"key":"10.1160\/TH15-05-0381-17","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.038083"},{"key":"10.1160\/TH15-05-0381-18","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"10.1160\/TH15-05-0381-19","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"10.1160\/TH15-05-0381-20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-619122"},{"key":"10.1160\/TH15-05-0381-21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000078468.11849.66"},{"key":"10.1160\/TH15-05-0381-22","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-9-199805010-00006"},{"key":"10.1160\/TH15-05-0381-23","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00766-9"},{"key":"10.1160\/TH15-05-0381-24","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-014-1163-7"},{"key":"10.1160\/TH15-05-0381-25","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01095-4"},{"key":"10.1160\/TH15-05-0381-26","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2010.0325"},{"key":"10.1160\/TH15-05-0381-27","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182a9d11d"},{"key":"10.1160\/TH15-05-0381-28","doi-asserted-by":"crossref","unstructured":"Brakenridge SC, Henley SS, Kashner TM, et al.; Inflammation and the Host Response to Injury Investigators. Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? J Trauma Acute Care Surg 2013; 74: 1231-1237","DOI":"10.1097\/TA.0b013e31828cc9a0"},{"key":"10.1160\/TH15-05-0381-29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03849.x"},{"key":"10.1160\/TH15-05-0381-30","first-page":"110","volume":"150","author":"Kim","year":"2015","journal-title":"J Am Med Assoc Surg"},{"key":"10.1160\/TH15-05-0381-31","unstructured":"Kimmell KT, Jahromi BS. Clinical factors associated with venous thromboembolism risk in patients undergoing craniotomy. J Neurosurg 2014; 1-8"},{"key":"10.1160\/TH15-05-0381-32","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000466"},{"key":"10.1160\/TH15-05-0381-33","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1978.01370190030004"},{"key":"10.1160\/TH15-05-0381-34","first-page":"264","volume":"39","author":"Visudhiphan","year":"1985","journal-title":"Biomed Pharmacother"},{"key":"10.1160\/TH15-05-0381-35","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21319"},{"key":"10.1160\/TH15-05-0381-36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08059.x"},{"key":"10.1160\/TH15-05-0381-37","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"10.1160\/TH15-05-0381-38","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-01-0010"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH15-05-0381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T18:02:56Z","timestamp":1691949776000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH15-05-0381"}},"subtitle":["A nationwide cohort study"],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":38,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,11,22]]},"published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1160\/th15-05-0381","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}