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In the process of plaque rupture, composition, biology and mechanics each play a role, but the latter has been disregarded in many animal studies. The biomechanical environment for atherosclerotic plaques is comprised of two parts, the pressure-induced stress distribution, mainly - but not exclusively \u2013 influenced by plaque composition, and the strength distribution throughout the plaque, largely determined by the inflammatory state. This environment differs considerably between humans and most animals, resulting in suboptimal conditions for plaque rupture. In this review we describe the role of the biomechanical environment in plaque rupture and assess this environment in animal models that present with plaque rupture.<\/jats:p>","DOI":"10.1160\/th15-07-0614","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T12:06:24Z","timestamp":1448539584000},"page":"501-508","source":"Crossref","is-referenced-by-count":28,"title":["Animal models for plaque rupture: a biomechanical assessment"],"prefix":"10.1160","volume":"115","author":[{"given":"Mat J.","family":"Daemen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J. 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