{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:46Z","timestamp":1787017966117,"version":"build-2736575974"},"reference-count":64,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Increased plasma levels of von Willebrand factor antigen (vWF:Ag) are associated with high risk of coronary artery disease. The effect of statin therapy on vWF:Ag levels remains uncertain. Therefore the aim of this meta-analysis was to evaluate the effect of statin therapy on vWF:Ag Levels. A systematic multiple-database search was carried out to identify randomized controlled trials (RCTs) that investigated the effect of statins on plasma vWF:Ag levels. Random-effect meta-analysis of 21 treatment arms revealed a significant decrease in plasma vWF:Ag levels following statin therapy (SMD: \u22120.54, 95 %CI: \u22120.87, \u22120.21, p=0.001). In subgroup analyses, the greatest effect was observed with simvastatin (SMD: \u22121.54, 95 %CI: \u22122.92, \u22120.17, p=0.028) and pravastatin (SMD: \u22120.61, 95 %CI: \u22121.18, \u22120.04, p=0.035), but not with fluvastatin (SMD: \u22120.34, 95 %CI: \u22120.69, 0.02, p=0.065), atorvastatin (SMD: \u22120.23, 95 %CI: \u22120.57, 0.11, p=0.179) and rosuvastatin (SMD: \u22120.20, 95 %CI: \u22120.71, 0.30, p=0.431). The lowering effect of statins on plasma vWF:Ag levels was greater in the subset of studies lasting \u2265 12 weeks (SMD: \u22120.70, 95 %CI: \u22121.19, \u22120.22, p=0.005) compared with that of studies lasting &gt; 12 weeks (SMD: \u22120.34, 95 %CI: \u22120.67, 0.003, p=0.052). Finally, low-intensity statin therapy was not associated with a significant reduction in vWF:Ag levels (SMD: \u22120.28, 95 %CI: \u22120.82, 0.27, p=0.320), but a significant effect was observed in high-intensity statin trials (SMD: \u22120.66, 95 %CI: \u22121.07, \u22120.24, p=0.002). This meta-analysis of available RCTs demonstrates a significant reduction in plasma vWF:Ag levels following statin therapy.<\/jats:p>\n                  <jats:p>Note: The review process for this manuscript was fully handled by Christian Weber, Editor in Chief.<\/jats:p>","DOI":"10.1160\/th15-08-0620","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T05:16:57Z","timestamp":1449119817000},"page":"520-532","source":"Crossref","is-referenced-by-count":161,"title":["The impact of statin therapy on plasma levels of von Willebrand factor antigen"],"prefix":"10.1160","volume":"115","author":[{"given":"Amirhossein","family":"Sahebkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Serban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Ursoniu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri P.","family":"Mikhailidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. 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