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Data were pooled using random-effects meta-analysis, and heterogeneity was assessed with I2 and Tau2 tests. SF-12, SF-36, and VEINES-QOL were evaluated with pooled standardised mean difference (SMD) and 95% confidence intervals (CI). Fourteen studies were included for meta-analysis. In patients who sustain a PE, physical health becomes impaired (p&lt;0.001, 2 studies) but mental health appears to remain similar to population norms (p=0.069, 2 studies) after at least one year. Patients who develop CTEPH report worse physical (p&lt;0.001, 1 study) and mental health (p=0.009, 1 study). In patients who suffer from a DVT, physical health (p=0.19, 9 studies), mental health (p=0.67, 9 studies), and disease specific quality of life (p=0.61, 8 studies) remain similar to population norms after at least one year. Patients who develop PTS, however, report worse physical health (p&lt;0.001, 7 studies), mental health (p&lt;0.001, 7 studies), and disease specific quality of life (p&lt;0.001, 10 studies). These data can be used to educate patients during the shared decision making process that increasingly governs medical care today. Level of Evidence: II.<\/jats:p><jats:p>Supplementary Material to this article is available online at www.thrombosis-online.com.<\/jats:p>","DOI":"10.1160\/th16-02-0152","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T05:27:23Z","timestamp":1467264443000},"page":"417-431","source":"Crossref","is-referenced-by-count":37,"title":["What is the effect of venous thromboembolism and related complications on patient reported health-related quality of life?"],"prefix":"10.1160","volume":"116","author":[{"given":"Nuno Rui","family":"Paulino Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kabrhel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Kuter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher 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