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Five studies including 403 patients met the inclusion criteria, 68 developed preeclampsia and 118 FGR. The studies were very heterogeneous in terms of inclusion criteria, LMWH preparation, and dosage. Meta-analyses were performed using random-effect models. The overall use of LMWHs was associated with a risk reduction for preeclampsia (Relative risk (RR) 0.366; 95 % confidence interval (CI), 0.219\u20130.614) and FGR (RR 0.409; 95 % CI, 0.195\u20130.932) vs. no treatment. From the data available for analysis it appears that the use of Dalteparin is associated with a risk reduction for preeclampsia (p=0.002) and FGR (p&lt;0.001); while Enoxaparin is associated with risk reduction for preeclampsia (p=0.013) but not for FGR (p=0.3). In spite of the small number of studies addressing the research question, and the high variability among them, our meta-analysis found a modest beneficial effect of LMWH for secondary prevention of preeclampsia and FGR. Further studies are needed to address these questions before a definite conclusion can be reached.<\/jats:p><jats:p>Supplementary Material to this article is available online at www.thrombosis-online.com.<\/jats:p>","DOI":"10.1160\/th16-02-0169","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T08:45:08Z","timestamp":1469090708000},"page":"868-878","source":"Crossref","is-referenced-by-count":42,"title":["LMWH in the prevention of preeclampsia and fetal growth restriction in women without thrombophilia"],"prefix":"10.1160","volume":"116","author":[{"given":"Salvatore","family":"Mastrolia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Novack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jecko","family":"Thachil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Rabinovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Pikovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vered","family":"Klaitman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Loverro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Offer","family":"Erez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,11]]},"reference":[{"key":"10.1160\/TH16-02-0169-1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000239439.04364.9a"},{"key":"10.1160\/TH16-02-0169-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71003-5"},{"key":"10.1160\/TH16-02-0169-3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2003.02069.x"},{"key":"10.1160\/TH16-02-0169-4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7394.845"},{"key":"10.1160\/TH16-02-0169-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.065"},{"key":"10.1160\/TH16-02-0169-6","doi-asserted-by":"crossref","unstructured":"Mor O, Stavsky M, Yitshak-Sade M, et al. 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