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MPs, in particular platelet- and endothelial-derived MPs (PMPs and EMPs), are increased in a wide range of thrombotic disorders, with an interesting relationship between their levels and disease pathophysiology, activity or progression. EMP plasma levels have been associated with several cardiovascular diseases and risk factors. PMPs are also shown to be involved in the progressive formation of atherosclerotic plaque and development of arterial thrombosis, especially in diabetic patients. Indeed, diabetes is characterised by an increased procoagulant state and by a hyperreactive platelet phenotype, with enhanced adhesion, aggregation, and activation. Elevated MP levels, such as TF+ MPs, have been shown to be one of the procoagulant determinants in patients with type 2 diabetes mellitus. Atherosclerotic plaque constitutes an opulent source of sequestered MPs, called \u201cplaque\u201d MPs. Otherwise, circulating MPs represent a TF reservoir, named \u201cblood-borne\u201d TF, challenging the dogma that TF is a constitutive protein expressed in minute amounts. \u201cBlood-borne\u201d TF is mainly harboured by PMPs, and it can be trapped within the developing thrombus. MP detection and enumeration by polychromatic flow cytometry (PFC) have opened interesting perspectives in clinical settings, particularly for the evaluation of MP numbers and phenotypes as independent marker of cardiovascular risk, disease and outcome in diabetic patients.<\/jats:p>","DOI":"10.1160\/th16-03-0176","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T06:21:37Z","timestamp":1463120497000},"page":"220-234","source":"Crossref","is-referenced-by-count":75,"title":["Microparticles as new markers of cardiovascular risk in diabetes and beyond"],"prefix":"10.1160","volume":"116","author":[{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marchisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Lanuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Boccatonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Miscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dav\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"10.1160\/TH16-03-0176-1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04007.x"},{"key":"10.1160\/TH16-03-0176-2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0198-4"},{"key":"10.1160\/TH16-03-0176-3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0689-3"},{"key":"10.1160\/TH16-03-0176-4","first-page":"2420","volume":"17","author":"Wu","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1160\/TH16-03-0176-5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061515"},{"key":"10.1160\/TH16-03-0176-6","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.9.2840"},{"key":"10.1160\/TH16-03-0176-7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq478"},{"key":"10.1160\/TH16-03-0176-8","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120309"},{"key":"10.1160\/TH16-03-0176-9","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-09-0720"},{"key":"10.1160\/TH16-03-0176-10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01196.x"},{"key":"10.1160\/TH16-03-0176-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.053"},{"key":"10.1160\/TH16-03-0176-12","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-013-1000-2"},{"key":"10.1160\/TH16-03-0176-13","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/250476"},{"key":"10.1160\/TH16-03-0176-14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"10.1160\/TH16-03-0176-15","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.194589"},{"key":"10.1160\/TH16-03-0176-16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.2.224"},{"key":"10.1160\/TH16-03-0176-17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.1.69"},{"key":"10.1160\/TH16-03-0176-18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.841"},{"key":"10.1160\/TH16-03-0176-19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00103-0"},{"key":"10.1160\/TH16-03-0176-20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148128"},{"key":"10.1160\/TH16-03-0176-21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1674"},{"key":"10.1160\/TH16-03-0176-22","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12254"},{"key":"10.1160\/TH16-03-0176-23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04610.x"},{"key":"10.1160\/TH16-03-0176-24","doi-asserted-by":"publisher","DOI":"10.2741\/1270"},{"key":"10.1160\/TH16-03-0176-25","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0250-3"},{"key":"10.1160\/TH16-03-0176-26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04047.x"},{"key":"10.1160\/TH16-03-0176-27","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-09-0595"},{"key":"10.1160\/TH16-03-0176-28","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.06.004"},{"key":"10.1160\/TH16-03-0176-29","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.12.014"},{"key":"10.1160\/TH16-03-0176-30","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-07-0509"},{"key":"10.1160\/TH16-03-0176-31","doi-asserted-by":"crossref","unstructured":"Dignat-George F, et al. 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