{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:45Z","timestamp":1787017965916,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"NMRPG","award":["3E6091\u20132"],"award-info":[{"award-number":["3E6091\u20132"]}]},{"name":"CMRPG","award":["5D0061"],"award-info":[{"award-number":["5D0061"]}]},{"name":"NMRPG","award":["3E6091\u20132"],"award-info":[{"award-number":["3E6091\u20132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The interaction between platelets and monocytes plays a critical role in the pathogenesis and progression of cardiovascular diseases. This study investigated how short-term intensive training (SIT) influences monocyte subset characteristics and exercise-induced monocyte and platelet aggregates (MPAs) following elective coronary bypass (CABG) in cardiac patients. Forty-nine patients hospitalised for CABG were randomised into SIT (N=26) and conventional training (CT, N=23) groups. The SIT subjects underwent supervised aerobic training at 80\u223c120 % of the ventilatory anaerobic threshold based on sub-maximal exercise tests performed 7 days post-CABG for 20 sessions with two sessions\/day and 30 min\/session, which were completed within four weeks after surgery. The CT subjects performed light-intensity conditioning exercise for \u22644 sessions. Resting and maximal exercise-mediated monocyte characteristics and MPA were determined before and following intervention. The SIT group had a larger improvement in ventilation efficiency and anaerobic threshold than the CT group; the SIT group exhibited larger reductions in blood monocyte subtypes 1 and 2 (Mono1 and 2) counts at rest than the CT group; the SIT group but not the CT group exhibited attenuated formation of Mono1\/platelet hetero-aggregation (MPA1) and CD42b expression on Mono1\/2 caused by strenuous exercise; and plasma levels of macrophage inflammatory protein-1\u03b2 and soluble P-selectin showed similar trends as Mono1\/2 and MPA1, respectively. In conclusion, SIT modestly improved aerobic capacity in patients following CABG. Moreover, SIT simultaneously ameliorated the CD42b expression of Mono1\/2 cells and maximal exercise-induced MPA1, which may reduce the risk of inflammatory thrombosis.<\/jats:p>\n                  <jats:p>Supplementary Material to this article is available online at www.thrombosis-online.com.<\/jats:p>","DOI":"10.1160\/th17-03-0184","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T09:48:49Z","timestamp":1494496129000},"page":"1761-1771","source":"Crossref","is-referenced-by-count":7,"title":["Short-term intensive training attenuates the exercise-induced interaction of mono-1\/2 cells and platelets after coronary bypass in cardiac patients"],"prefix":"10.1160","volume":"117","author":[{"given":"Shu-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Kuen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyng-Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chun","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw-Ji","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieh-Cheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Shyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"10.1160\/TH17-03-0184-1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.228"},{"key":"10.1160\/TH17-03-0184-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04244.x"},{"key":"10.1160\/TH17-03-0184-3","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7771-2-1"},{"key":"10.1160\/TH17-03-0184-4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.960385"},{"key":"10.1160\/TH17-03-0184-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.019"},{"key":"10.1160\/TH17-03-0184-6","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0412"},{"key":"10.1160\/TH17-03-0184-7","first-page":"7266","volume":"8","author":"Zhu","year":"2015","journal-title":"Int 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