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Membrane budding gives rise to microparticles (MPs), another active participant within the blood stream. Platelets are essential for the innate immune response and combat infection (viruses, bacteria, micro-organisms). They help maintain and modulate inflammation and are a major source of pro-inflammatory molecules (e.g. P-selectin, tissue factor, CD40L, metalloproteinases). As well as promoting coagulation, they are active in fibrinolysis; wound healing, angiogenesis and bone formation as well as in maternal tissue and foetal vascular remodelling. Activated platelets and MPs intervene in the propagation of major diseases. They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth. They participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth. The above mentioned roles of platelets are now discussed.<\/jats:p>","DOI":"10.1160\/ths10-11-0720","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T09:28:22Z","timestamp":1302514102000},"page":"S13-S33","source":"Crossref","is-referenced-by-count":536,"special_numbering":"S","title":["Platelets, inflammation and tissue regeneration"],"prefix":"10.1160","volume":"105","author":[{"given":"Alan","family":"Nurden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"10.1160\/THS10-11-0720-1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00304.x"},{"key":"10.1160\/THS10-11-0720-2","doi-asserted-by":"publisher","DOI":"10.2741\/2947"},{"key":"10.1160\/THS10-11-0720-3","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1182\/blood.V93.9.2984","volume":"93","author":"Zhang","year":"1999","journal-title":"Blood"},{"key":"10.1160\/THS10-11-0720-4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3607"},{"key":"10.1160\/THS10-11-0720-5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601430"},{"key":"10.1160\/THS10-11-0720-6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00902.x"},{"key":"10.1160\/THS10-11-0720-7","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1172\/JCI200422123","volume":"114","author":"Boucharaba","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1160\/THS10-11-0720-8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040980"},{"key":"10.1160\/THS10-11-0720-9","doi-asserted-by":"crossref","unstructured":"Lefebvre JS, Marleau S, Milot V, et al. 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