{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:38:58Z","timestamp":1766140738811,"version":"3.48.0"},"reference-count":22,"publisher":"Pan African Medical Journal","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pan Afr Med J"],"abstract":"<jats:p>Introduction: la r\u00e9ponse th\u00e9rapeutique aux bioth\u00e9rapies dans la polyarthrite rhumato\u00efde (PR) demeure h\u00e9t\u00e9rog\u00e8ne, influenc\u00e9e par divers facteurs cliniques, biologiques et comorbidit\u00e9s. L'objectif de cette \u00e9tude \u00e9tait d'identifier les facteurs associ\u00e9s \u00e0 une bonne r\u00e9ponse clinique aux bioth\u00e9rapies chez des patients atteints de PR suivis dans un contexte nord-africain.\nM\u00e9thodes: une \u00e9tude observationnelle transversale a \u00e9t\u00e9 men\u00e9e au Service de Rhumatologie de l'H\u00f4pital Militaire d'Instruction Mohammed V de Rabat entre janvier et d\u00e9cembre 2024. Les donn\u00e9es sociod\u00e9mographiques, cliniques, biologiques et comorbidit\u00e9 des patients trait\u00e9s par bioth\u00e9rapie ont \u00e9t\u00e9 recueillies au moment de leur suivi. Une r\u00e9gression logistique multivari\u00e9e a \u00e9t\u00e9 r\u00e9alis\u00e9e afin d'identifier les facteurs ind\u00e9pendamment associ\u00e9s \u00e0 une bonne r\u00e9ponse clinique selon les crit\u00e8res de l'European League Against Rheumatism (EULAR).\nR\u00e9sultats: cent cinquante-trois patients ont \u00e9t\u00e9 inclus, dont 75,8% de femmes (\u00e2ge moyen: 57,5 \u00b1 13,7 ans). En analyse multivari\u00e9e, la positivit\u00e9 des anticorps anti-CCP (ORa = 3,15; IC95%: 1,62-6,14; P = .001) et un d\u00e9lai d'instauration de la bioth\u00e9rapie \u2264 1 an (ORa = 4,55; IC95%: 2,12-9,76; P &lt; .001) \u00e9taient significativement associ\u00e9s \u00e0 une meilleure r\u00e9ponse clinique. \u00c0 l'inverse, une CRP &gt; 15 mg\/L (ORa = 0,29; IC95%: 0,14-0,63; P &lt; 0,001) et la pr\u00e9sence d'un diab\u00e8te (ORa = 0,33; IC95%: 0,15-0,74; P = 0,003) \u00e9taient associ\u00e9es \u00e0 une r\u00e9ponse d\u00e9favorable.\nConclusion: la positivit\u00e9 des anticorps anti-CCP et l'instauration pr\u00e9coce d'une bioth\u00e9rapie sont associ\u00e9es \u00e0 une meilleure r\u00e9ponse clinique, tandis qu'un taux \u00e9lev\u00e9 de CRP et la pr\u00e9sence d'un diab\u00e8te sont li\u00e9s \u00e0 une \u00e9volution moins favorable. Ces r\u00e9sultats soulignent la n\u00e9cessit\u00e9 d'une prise en charge pr\u00e9coce et individualis\u00e9e de la PR, en particulier dans les contextes \u00e0 ressources limit\u00e9es.<\/jats:p>","DOI":"10.11604\/pamj.2025.52.172.47745","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:35:17Z","timestamp":1766140517000},"source":"Crossref","is-referenced-by-count":0,"title":["Facteurs pr\u00e9dictifs de la r\u00e9ponse aux bioth\u00e9rapies chez les patients atteints de polyarthrite rhumato\u00efde : \u00e9tude observationnelle transversale men\u00e9e au Service de Rhumatologie de l\u00b4H\u00f4pital Militaire d\u00b4Instruction Mohammed V, Rabat (Maroc)"],"prefix":"10.11604","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6527-5633","authenticated-orcid":false,"given":"Mahamadou","family":"Sagara","sequence":"first","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Militaire d'Instruction Mohammed V, Rabat, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abderrahim","family":"Majjad","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Militaire d'Instruction Mohammed V, Facult\u00e9 de M\u00e9decine, de Pharmacie de Rabat, Rabat, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-8877","authenticated-orcid":false,"given":"Toufik","family":"Hamza","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Militaire d'Instruction Mohammed V, Facult\u00e9 de M\u00e9decine, de Pharmacie de Rabat, Rabat, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Bezza","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Militaire d'Instruction Mohammed V, Facult\u00e9 de M\u00e9decine, de Pharmacie de Rabat, Rabat, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4870","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C. 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