{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:57:48Z","timestamp":1780095468232,"version":"3.54.0"},"reference-count":8,"publisher":"Pan African Medical Journal","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pan Afr Med J"],"abstract":"<jats:p>La maladie de Castleman est une pathologie lymphoprolif\u00e9rative rare. Elle se manifeste par une lymphad\u00e9nopathie et peut \u00eatre associ\u00e9e \u00e0 des manifestations syst\u00e9miques parfois s\u00e9v\u00e8res. Elle peut se pr\u00e9senter sous forme unicentrique limit\u00e9e \u00e0 un seul ganglion ou \u00e0 une seule r\u00e9gion ganglionnaire et est g\u00e9n\u00e9ralement de bon pronostic. Son traitement repose essentiellement sur l'ex\u00e9r\u00e8se chirurgicale, ou multicentrique plus s\u00e9v\u00e8re, caract\u00e9ris\u00e9e par une atteinte ganglionnaire diffuse et une hyperproduction de cytokines, notamment l'Interleukine-6 (IL-6), expliquant les manifestations syst\u00e9miques. Le traitement fait appel aux anticorps monoclonaux ciblant l'IL-6, immunosuppresseurs, chimioth\u00e9rapie ou corticoth\u00e9rapie en fonction de l'\u00e9tiologie. Elle peut \u00eatre associ\u00e9e \u00e0 l'infection par l'herp\u00e8s virus humain type 8 (HHV-8), notamment chez les patients immunod\u00e9prim\u00e9s. Nous rapportons le cas d'un patient de 65 ans pr\u00e9sentant une polyad\u00e9nopathie associ\u00e9e \u00e0 un syndrome de Raynaud. L'imagerie a mis en \u00e9vidence des ad\u00e9nopathies multiples ainsi qu'une h\u00e9patospl\u00e9nom\u00e9galie. Une cervicotomie exploratrice a \u00e9t\u00e9 r\u00e9alis\u00e9e, suivie d'une analyse anatomopathologique et d'un examen immunohistochimique, ayant permis de poser le diagnostic de maladie de Castleman multicentrique. Ce cas clinique illustre l'importance de consid\u00e9rer cette pathologie dans le cadre du bilan \u00e9tiologique des polyad\u00e9nopathies inexpliqu\u00e9es, en particulier lorsqu'elles s'accompagnent de manifestations syst\u00e9miques atypiques.<\/jats:p>","DOI":"10.11604\/pamj.2025.52.84.48274","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:47:01Z","timestamp":1763045221000},"source":"Crossref","is-referenced-by-count":1,"title":["Maladie de Castleman avec manifestation syst\u00e9mique: \u00e0 propos d'un cas"],"prefix":"10.11604","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7650-6926","authenticated-orcid":false,"given":"Ahlam","family":"Hmimsa","sequence":"first","affiliation":[{"name":"Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, H\u00f4pital Militaire Moulay Ismail, Mekn\u00e8s, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Touihem","sequence":"additional","affiliation":[{"name":"Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, H\u00f4pital Militaire Moulay Ismail, Mekn\u00e8s, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Attifi","sequence":"additional","affiliation":[{"name":"Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, H\u00f4pital Militaire Moulay Ismail, Mekn\u00e8s, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounir","family":"Hmidi","sequence":"additional","affiliation":[{"name":"Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, H\u00f4pital Militaire Moulay Ismail, Mekn\u00e8s, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4870","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Fajgenbaum DC, Shilling D. Castleman Disease Pathogenesis. Hematol Oncol Clin North Am. 2018 Feb;32(1):11-21. PubMed | Google Scholar","DOI":"10.1016\/j.hoc.2017.09.002"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med. 1954 Jun 10;250(23):1001-5. PubMed","DOI":"10.1056\/NEJM195406102502308"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Oksenhendler E, Boulanger E, Galicier L, Du MQ, Dupin N, Martin A et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in HIV-infected patients with multicentric Castleman disease. Blood. 2002 Apr 1;99(7):2331-6. PubMed | Google Scholar","DOI":"10.1182\/blood.V99.7.2331"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"van Rhee F, Oksenhendler E, Srkalovic G, Voorhees PM, Lim MS, Leblanc R et al. International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. Blood Adv. 2020 Dec 8;4(23):6039-6050. PubMed | Google Scholar","DOI":"10.1182\/bloodadvances.2020003334"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K et al. Pathogenic significance of interleukin-6 (IL-6\/BSF-2) in Castleman's disease. Blood. 1989 Sep;74(4):1360-7. PubMed | Google Scholar","DOI":"10.1182\/blood.V74.4.1360.bloodjournal7441360"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"van Rhee F, Voorhees PM, Dispenzieri A, Foss\u00e5 A, Srkalovic G, Ide M et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood. 2018 Nov 15;132(20):2115-2124. PubMed | Google Scholar","DOI":"10.1182\/blood-2018-07-862334"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"El-Osta H, Kurzrock R. Castleman's disease: from basic mechanisms to molecular therapeutics. Oncologist. 2011;16(4):497-511. PubMed | Google Scholar","DOI":"10.1634\/theoncologist.2010-0212"},{"key":"ref7","unstructured":"Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood. 2017 Mar 23;129(12):1646-1657. PubMed | Google Scholar"}],"container-title":["Pan African Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:47:04Z","timestamp":1763045224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.panafrican-med-journal.com\/content\/article\/52\/84\/full\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":8,"URL":"https:\/\/doi.org\/10.11604\/pamj.2025.52.84.48274","relation":{},"ISSN":["1937-8688"],"issn-type":[{"value":"1937-8688","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"article-number":"48274"}}