{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:37:04Z","timestamp":1785425824016,"version":"3.56.0"},"reference-count":14,"publisher":"Pan African Medical Journal","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pan Afr Med J"],"abstract":"<jats:p>Les m\u00e9tastases, surtout osseuses, sont fr\u00e9quentes au cours de l'\u00e9volution de certains cancers et engagent le plus souvent le pronostic vital, voire le pronostic fonctionnel (compression m\u00e9dullaire) des patients. L'objectif de cette \u00e9tude est d'\u00e9valuer la survie des patients souffrant de m\u00e9tastases vert\u00e9brales au Togo. Nous avons men\u00e9 une \u00e9tude r\u00e9trospective de type transversal, descriptive et analytique de 5 ans, de 2016 \u00e0 2020 dans les services de rhumatologie des centres hospitaliers universitaires (CHU) Kara, Sylvanus Olympio et de l'h\u00f4pital de B\u00e8 du Togo, chez tous les patients diagnostiqu\u00e9s de m\u00e9tastases osseuses et\/ou m\u00e9tastases visc\u00e9rales d'une tumeur primitive. Le score de Tokuhashi a \u00e9t\u00e9 utilis\u00e9 dans notre. Une analyse de r\u00e9gression multivari\u00e9e a \u00e9t\u00e9 faite afin de d\u00e9terminer les facteurs associ\u00e9s. Nous avons collig\u00e9 82 patients avec une pr\u00e9dominance masculine (53 hommes, soit 64,63%), d'\u00e2ge moyen de 65 ans chez les hommes. Le cancer de la prostate \u00e9tait retrouv\u00e9 chez 46 patients (56,09%), suivi du sein chez 12 patients (14,63%). Les facteurs statistiquement associ\u00e9s au mauvais pronostic \u00e9taient la pr\u00e9sence d'une image radiographique lytique (ORa: 3,87; IC \u00e0 95%: 1,66 - 4,85) et d'une image mixte (ORa: 2,58; IC \u00e0 95%: 1,38 - 4,74) avec respectivement p&lt;0,004 et p&lt;0,001. Dans notre \u00e9tude, 63,3% des patients de ceux qui avaient un mauvais pronostic ont surv\u00e9cu moins de 6 mois (ORa: 4.99; IC \u00e0 95%: 7,26 - 40,0) avec p = 0,001. Une analyse multivari\u00e9e entre les tumeurs les plus fr\u00e9quentes et la survie selon le score de Tokuhashi, a retrouv\u00e9 que le cancer de la prostate (n = 46) \u00e9tait associ\u00e9 \u00e0 une survie m\u00e9diane r\u00e9elle de 17,9 mois (Ora: 0,23; IC \u00e0 95%: 0,11-0,48); contre une survie pr\u00e9dite par le score de Tokuhashi de 9,87 mois. Le cancer du sein (n = 12) montrait une survie r\u00e9elle de 9,87 mois (ORa: 0,48; IC \u00e0 95%: 0,21-1,14) avec une survie pr\u00e9dite de 8,92 mois. Les m\u00e9tastases osseuses sont associ\u00e9es \u00e0 une morbidit\u00e9 importante et \u00e0 la survie des patients. La pr\u00e9sence d'une image radiographique lytique et d'une image mixte est le facteur statistiquement significatif de mauvais pronostic. Le cancer de la prostate et celui du sein sont les cancers les plus fr\u00e9quents et statistiquement associ\u00e9s \u00e0 la survie des patients selon le score de Tokuhashi avec une survie r\u00e9elle de 17,9 mois contre une survie pr\u00e9dite par le score de Tokuhashi de 9,87 mois et cancer du sein avec une survie r\u00e9elle de 9,87 mois contre une survie pr\u00e9dite de 8,82.<\/jats:p>","DOI":"10.11604\/pamj.2026.53.90.49285","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:33:23Z","timestamp":1774272803000},"source":"Crossref","is-referenced-by-count":0,"title":["\u00c9tude analytique et descriptive de la survie des patients atteints de m\u00e9tastases vert\u00e9brales en milieu rhumatologique au Togo"],"prefix":"10.11604","author":[{"given":"Sadat","family":"Oniankitan","sequence":"first","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire de Kara, Kara, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou Lamine","family":"Diallo","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire Ignace Deen, Conakry, Guin\u00e9e"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-3797","authenticated-orcid":false,"given":"Eyram","family":"Fianyo","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier R\u00e9gional de Lom\u00e9 Commune, Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4580-9524","authenticated-orcid":false,"given":"Awaki Esso","family":"Atak\u00e9","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire de Syvanus Olympio, Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou Ba\u00eflo","family":"Diallo","sequence":"additional","affiliation":[{"name":"Disease Prevention and Control Department, Distric Heath Management Board, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagbor Cyril","family":"Komi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04g47ec58","id-type":"ROR","asserted-by":"publisher"}],"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viwale Etonam","family":"Sika Koffi-Tessio","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier R\u00e9gional de Ts\u00e9vi\u00e9, Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodjo","family":"Kakpovi","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier R\u00e9gional de Kara, Kara, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prenam","family":"Houzou","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire de Kara, Kara, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owonayo","family":"Oniankitan","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire de Syvanus Olympio, Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4870","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Bonetto R, Tallet A, M\u00e9lot A, Calderon B, Barlesi F. Prise en charge des m\u00e9tastases osseuses [The management of bone metastasis]. Bull Cancer. 2017 Jun;104(6):585-592. PubMed | Google Scholar","DOI":"10.1016\/j.bulcan.2017.02.004"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Marchal C, Belhassen M, D\u00e9sam\u00e9ricq G, Lehmann E, Walter M, Bosco-Levy P et al. Epidemiology of bone metastasis in France between 2009 and 2018. JBMR Plus. 2025 May 6;9(8):ziaf081. PubMed | Google Scholar","DOI":"10.1093\/jbmrpl\/ziaf081"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Nwatsock JF, Kofane JA. Aspects et pronostic scintigraphiques des m\u00e9tastases osseuses au Cameroun : bilan de 1278 explorations au service de M\u00e9decine nucl\u00e9aire de l'H\u00f4pital G\u00e9n\u00e9ral de Yaound\u00e9 de 2004 \u00e0 2019 J Afr Imag M\u00e9d; 2021; 13 (1): 46-52. Google Scholar","DOI":"10.55715\/jaim.v13i1.194"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Tour\u00e9 MI, Sangar\u00e9 F, Tour\u00e9 S, Diallo S, Diakit\u00e9 F, Pamanta IS et al. Profil \u00e9pid\u00e9mio-clinique des m\u00e9tastases osseuses dans le service de rhumatologie du CHU Point G; Rev Rhum; 2020; 87: 236-A237. Google Scholar","DOI":"10.1016\/j.rhum.2020.10.422"},{"key":"ref4","unstructured":"Kakpovi K, Oniankitan O, Kpoti M, Houzou P, Es Koffi-Tessio V, Tagbor KC. Profile of bone malignancy among rheumatology inpatients in Lom\u00e9 (Togo). Tunis Med. 2016 Aug-Sep;94(8-9):546-550. PubMed | Google Scholar"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306. PubMed | Google Scholar","DOI":"10.1097\/00007632-200102010-00016"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S. Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 1990 Nov;15(11):1110-3. PubMed | Google Scholar","DOI":"10.1097\/00007632-199011010-00005"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Katagiri H, Takahashi M, Wakai K, Sugiura H, Kataoka T, Nakanishi K. Prognostic factors and a scoring system for patients with skeletal metastasis. J Bone Joint Surg Br. 2005 May;87(5):698-703. PubMed | Google Scholar","DOI":"10.1302\/0301-620X.87B5.15185"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Frankel HL, Hancock DO, Hyslop G, Melzak J, Michaelis LS, Ungar GH et al. The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. I. Paraplegia. 1969 Nov;7(3):179-92. PubMed | Google Scholar","DOI":"10.1038\/sc.1969.30"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Bouthors C, Laumonerie P, Crenn V, Prost S, Blondel B, Fuentes S et al. Surgical treatment of bone metastasis from osteophilic cancer. Results in 401 peripheral and spinal locations. Orthop Traumatol Surg Res. 2022 Jun;108(4):103193. PubMed | Google Scholar","DOI":"10.1016\/j.otsr.2021.103193"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Arrigo RT, Kalanithi P, Cheng I, Alamin T, Carragee EJ, Stefan A et al. Predictors of survival after surgical treatment of spinal metastasis. Neurosurgery. 2011 Mar;68(3):674-81; discussion 681. PubMed | Google Scholar","DOI":"10.1227\/NEU.0b013e318207780c"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Tatsui H, Onomura T, Morishita S, Oketa M, Inoue T. Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. Spine (Phila Pa 1976). 1996 Sep 15;21(18):2143-8. PubMed | Google Scholar","DOI":"10.1097\/00007632-199609150-00017"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Haman NO, Bello B, Ndome Toto O, Nchufor RN, Bakop ND, Anu RF et al. Diagnostic Methods, Management and Prognosis at the Yaounde Central Hospital and Yaounde General Hospital. Open Journal of Modern Neurochirurgery; 2024; 14 (4) 158-169.","DOI":"10.4236\/ojmn.2024.142017"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Eap C, Tardieux E, Goasgen O, Bennis S, Mireau E, Delalande D et al. Tokuhashi score and other prognostic factors in 260 patients with surgery for vertebral metastases. Orthop Traumatol Surg Res. 2015 Jun;101(4):483-8. PubMed | Google Scholar","DOI":"10.1016\/j.otsr.2015.03.007"}],"container-title":["Pan African Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:33:26Z","timestamp":1774272806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.panafrican-med-journal.com\/content\/article\/53\/90\/full\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":14,"URL":"https:\/\/doi.org\/10.11604\/pamj.2026.53.90.49285","relation":{},"ISSN":["1937-8688"],"issn-type":[{"value":"1937-8688","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"article-number":"49285"}}