{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T19:31:36Z","timestamp":1698521496963},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arterioscler Thromb"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>Elevated levels of endogenous tissue-type plasminogen activator (t-PA) appear to be a marker for preclinical atherosclerosis. At present, however, data describing potential relations between plasma t-PA level and established lipid risk factors for coronary atherosclerosis are sparse. To explore these potential relations, we measured plasma levels of t-PA antigen (t-PA:ag) in 633 apparently healthy men in the Physicians' Health Study as well as total cholesterol, high-density lipoprotein (HDL) cholesterol, HDL2 cholesterol, HDL3 cholesterol, and apolipoproteins A-I, A-II, and B-100. Overall, plasma t-PA:ag levels were inversely correlated with HDL cholesterol (r = -.1616, P &lt; .0005), HDL2 cholesterol (r = -.1632, P &lt; .0005), and HDL3 cholesterol (r = -.0927, P = .019). In stratified analyses, the inverse association between t-PA:ag and HDL cholesterol was present among frequent (P trend = .002) and infrequent (P trend = .004) consumers of alcohol as well as among the subgroups of frequent exercisers (P trend &lt; .001), men in the lower half of body mass index (P trend = .001), and nonsmokers (P trend &lt; .001). In contrast, there was no association between t-PA:ag and total cholesterol (r = .0219, P = .58), whereas relations of t-PA:ag with apolipoproteins A-I, A-II, and B-100 were minimal and of borderline significance. These data indicate that plasma levels of endogenous t-PA:ag are inversely related to HDL cholesterol as well as HDL2 and HDL3 cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.atv.13.11.1587","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"1587-1592","source":"Crossref","is-referenced-by-count":8,"title":["A cross-sectional study of endogenous tissue plasminogen activator, total cholesterol, HDL cholesterol, and apolipoproteins A-I, A-II, and B-100."],"prefix":"10.1161","volume":"13","author":[{"given":"P M","family":"Ridker","sequence":"first","affiliation":[{"name":"Divisions of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D E","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Divisions of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Stampfer","sequence":"additional","affiliation":[{"name":"Divisions of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Sacks","sequence":"additional","affiliation":[{"name":"Divisions of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Hennekens","sequence":"additional","affiliation":[{"name":"Divisions of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Arteriosclerosis and Thrombosis: A Journal of Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.ATV.13.11.1587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:21:30Z","timestamp":1647526890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.ATV.13.11.1587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1161\/01.ATV.13.11.1587"],"URL":"https:\/\/doi.org\/10.1161\/01.atv.13.11.1587","relation":{},"ISSN":["1049-8834"],"issn-type":[{"value":"1049-8834","type":"print"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}