{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:56:10Z","timestamp":1760975770904},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arterioscler Thromb"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:p>The susceptibility of low-density lipoprotein (LDL) to oxidation was studied in hypertriglyceridemic men (5 with type III and 5 with type IV) at baseline on a low-saturated-fat, low-cholesterol diet, after 6 weeks of dietary supplementation with fish oil (Promega, 12 g\/d), and after 6 weeks of fish oil combined with probucol (500 mg BID). The relative content of n-3 polyunsaturated fatty acids in plasma and LDL was increased during the two treatment periods, and a low alpha-tocopherol to n-3 polyunsaturated fatty acids ratio was observed. Plasma thiobarbituric acid-reactive substances (TBARS) levels were unchanged after 6 weeks of fish oil, but the ratio of lipid peroxides to the reduced triglyceride (TG) levels (MDA:TG) was significantly higher (P &lt; .01). Addition of probucol lowered both absolute levels of TBARS (P &lt; .01) and the MDA to TG ratio (P &lt; .001). The susceptibility of LDL to Cu(2+)-catalyzed oxidation was evaluated over a 5-hour time course by determining TBARS formation, free amino group levels, and changes in LDL electrophoretic mobility. TBARS levels that were higher in native LDL (1.019 &lt; d &lt; 1.050 g\/mL) after 6 weeks of fish oil than at baseline (P &lt; .01) were reduced 52.3 +\/- 11.3% by the addition of probucol (P &lt; .001). With fish oil alone, TBARS production after exposure of LDL to Cu2+ for 5 hours was increased 17.0 +\/- 5.8% compared with corresponding baseline values (P &lt; .001), whereas a 64.1 +\/- 14.3% reduction from the previous period was observed with fish oil + probucol (P &lt; .001).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.atv.13.12.1790","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"1790-1797","source":"Crossref","is-referenced-by-count":36,"title":["Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients."],"prefix":"10.1161","volume":"13","author":[{"given":"S","family":"Lussier-Cacan","sequence":"first","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dubreuil-Quidoz","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Roederer","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Leboeuf","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Boulet","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"de Langavant","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Davignon","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Naruszewicz","sequence":"additional","affiliation":[{"name":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Arteriosclerosis and Thrombosis: A Journal of Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.ATV.13.12.1790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T18:16:30Z","timestamp":1647540990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.ATV.13.12.1790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1993,12]]}},"alternative-id":["10.1161\/01.ATV.13.12.1790"],"URL":"https:\/\/doi.org\/10.1161\/01.atv.13.12.1790","relation":{},"ISSN":["1049-8834"],"issn-type":[{"value":"1049-8834","type":"print"}],"subject":[],"published":{"date-parts":[[1993,12]]}}}