{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:26:33Z","timestamp":1760189193875},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arterioscler Thromb"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:p>In 748 probands and 3,283 first-degree relatives from the Collaborative Lipid Research Clinics (LRC) Family Study, our specific aim was to examine the degree to which low (bottom decile) high density lipoprotein cholesterol (HDL-C, hypoalpha) and high (top decile) triglyceride (TG, hyperTG) levels occur conjointly (CT) and the extent to which these characteristics were shared within families. To control for family size and permit a comparison with the proband percentages, mean familial percentages of HDL-C\/TG abnormalities were calculated. Concurrent low HDL-C and high TG levels were present in 2.7% of the probands, a value that was enriched to 12.7% (p = 0.003) of their associated first-degree relatives. If the proband had a low HDL-C value, 7.7% (p = 0.013) of relatives had CT. Familial (proband and at least one first-degree family member share the same lipoprotein\/lipid phenotype) hypoalpha was observed in 2.4% of families while familial hyperTG was observed in 4.1%. Familial CT was seen in approximately 0.7%. If the proband had CT, 80% of their families had at least one other first-degree member with an HDL-C\/TG abnormality, whereas the corresponding percentage for families associated with probands with only hypoalpha was 64% and for those with hyperTG alone, 54%. A broadly shared environmental factor cannot easily explain the familial association of hypoalpha, hyperTG, and CT. In probands with low HDL-C values alone or the conjoint low-HDL-C\/high-TG trait, family screening is extremely valuable because low HDL-C\/high TG is enriched in the respective family members, a conjoined trait closely associated with increased coronary heart disease risk.<\/jats:p>","DOI":"10.1161\/01.atv.13.4.495","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"495-504","source":"Crossref","is-referenced-by-count":16,"title":["The low HDL cholesterol\/high triglyceride trait."],"prefix":"10.1161","volume":"13","author":[{"given":"D L","family":"Sprecher","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Cincinnati, Ohio 45267."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"Feigelson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Cincinnati, Ohio 45267."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Laskarzewski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Cincinnati, Ohio 45267."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Arteriosclerosis and Thrombosis: A Journal of Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.ATV.13.4.495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T17:18:09Z","timestamp":1647537489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.ATV.13.4.495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1161\/01.ATV.13.4.495"],"URL":"https:\/\/doi.org\/10.1161\/01.atv.13.4.495","relation":{},"ISSN":["1049-8834"],"issn-type":[{"value":"1049-8834","type":"print"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}