{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:43Z","timestamp":1790794783466,"version":"4.1.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            Triglyceride-rich lipoprotein (TRL) remnants have been strongly implicated in the pathogenesis of atherosclerosis. To further investigate plasma remnant lipoprotein metabolism, we have determined the plasma concentration of apolipoprotein (apo) E (by polyclonal enzyme-linked immunoassay) in remnant-like lipoproteins, isolated by automated gel filtration chromatography as a fraction intermediate in size between VLDL and HDL. In normolipidemic subjects (n=12), 1.2\u00b10.1 mg\/dL (33\u00b12%, mean\u00b1SE) of total plasma apoE was associated with this fraction (termed ISL apoE). In hypercholesterolemic (type IIa, n=12), hypertriglyceridemic (type IV, n=12), and mixed hyperlipidemic (type IIb, n=12) subjects, mean ISL apoE concentrations were 2.1\u00b10.2, 2.5\u00b10.2, and 3.8\u00b10.4 mg\/dL, respectively (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001 versus normal values) (45\u00b12%, 32\u00b12%, and 44\u00b12% of total). ISL apoE was 8.7\u00b11.4 mg\/dL (42\u00b13%) in type III dyslipidemic subjects (apoE2\/2, n=8). ISL apoE was positively correlated with plasma triglyceride (\n            <jats:italic>r<\/jats:italic>\n            =.41,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01), and at any given level of plasma triglyceride, subjects with an apoE2\/2 or apoE3\/2 phenotype tended to have a higher concentration of ISL apoE (\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) than apoE3\/3 or E4\/3 individuals. ISL apoE was also correlated (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) with total plasma cholesterol (\n            <jats:italic>r<\/jats:italic>\n            =.66), TRL cholesterol (\n            <jats:italic>r<\/jats:italic>\n            =.49), TRL apoE (\n            <jats:italic>r<\/jats:italic>\n            =.47), LDL apoB (\n            <jats:italic>r<\/jats:italic>\n            =.42), and LDL+HDL triglyceride (\n            <jats:italic>r<\/jats:italic>\n            =.74). These results suggest that (1) a significant proportion of plasma apoE resides within an intermediate-sized remnant-like lipoprotein fraction in both normolipidemic and hyperlipidemic subjects; (2) plasma remnant lipoprotein accumulation is associated with an elevation in ISL apoE concentration; and (3) ISL apoE concentration is significantly correlated with various proatherogenic lipid parameters and may itself be a potentially important atherogenic index.\n          <\/jats:p>","DOI":"10.1161\/01.atv.16.1.149","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"149-159","source":"Crossref","is-referenced-by-count":79,"title":["Plasma Concentration of Apolipoprotein E in Intermediate-Sized Remnant-Like Lipoproteins in Normolipidemic and Hyperlipidemic Subjects"],"prefix":"10.1161","volume":"16","author":[{"given":"Jeffrey S.","family":"Cohn","sequence":"first","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Tremblay","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Amiot","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bouthillier","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Roy","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jacques","family":"Genest","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Davignon","sequence":"additional","affiliation":[{"name":"From the Hyperlipidemia and Atherosclerosis Research Group and the Cardiovascular Genetics Laboratory (J.G.), Clinical Research Institute of Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31426-2"},{"key":"e_1_3_2_2_2","unstructured":"Mahley RW Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. 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