{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:30:26Z","timestamp":1790854226022,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>The relationship between the apolipoprotein E (apoE) and \u03b2-fibrinogen G\/A-455 polymorphisms and cerebrovascular disease (CVD) was examined in the present study. We compared 227 patients with the subtypes of CVD (large-vessel disease, lacunar stroke, cardiac embolism, or undetermined pathomechanisms) with 225 control subjects. The occurrence of apoE isoforms (E2, E3, and E4) and the \u03b2-fibrinogen G\/A-455 genotype was determined in these individuals. No differences in apoE polymorphisms or allele frequencies between the CVD patients and control subjects were found. However, analysis of apoE genotypes as a function of stroke subtype revealed that the apoE4 allele was significantly more common in those patients with macroangiopathy-associated CVD. The only CVD risk factor that distinguished patients with the E4 allele from those with other apoE genotypes was elevated cholesterol. No association between the \u03b2-fibrinogen G\/A-455 polymorphism and CVD was found. However, homozygosity for the A allele was more common in patients with CVD resulting from large-vessel disease. These data demonstrate that the apoE4 allele and the AA genotype of the \u03b2-fibrinogen G\/A-455 polymorphism occur significantly more frequently in patients with CVD resulting from stenosis of large, brain-supplying vessels. Such genetic analyses may further our understanding of the etiology of cerebrovascular disease.<\/jats:p>","DOI":"10.1161\/01.atv.17.11.2880","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"2880-2884","source":"Crossref","is-referenced-by-count":90,"title":["The Apolipoprotein E and \u03b2-Fibrinogen G\/A-455 Gene Polymorphisms Are Associated With Ischemic Stroke Involving Large-Vessel Disease"],"prefix":"10.1161","volume":"17","author":[{"given":"Christof","family":"Kessler","sequence":"first","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Spitzer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Stauske","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Mende","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rg","family":"Stadlmu\u0308ller","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Walther","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rettig","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.S., C.K.), Institute of Clinical Chemistry (D.S.), Institute of Physiology (S.M., R.R.), and Institute of Biochemistry (R.W.), Ernst-Moritz-Arndt-University, Greifswald, and the Technology Transfer Unit Biotechnology (J.S., R.W.), Greifswald, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"World Development Report. 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