{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:10Z","timestamp":1790985610067,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>\u2014Antioxidants that prevent LDL from oxidation may reduce atherosclerosis.<jats:italic>Salvia miltiorrhiza<\/jats:italic>Bunge is a Chinese herb widely used for the treatment of atherosclerosis-related disorders. Salvianolic acid B (Sal B), a water-soluble polyphenolic antioxidant isolated from the roots of this plant, was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radicals and inhibit LDL oxidation more effectively than probucol. In order to evaluate the antiatherogenic potential, New Zealand White rabbits were fed for 12 weeks a normal diet, a high cholesterol diet, a high cholesterol diet containing 1% probucol, or a high cholesterol diet containing a 5% water-soluble extract of<jats:italic>S miltiorrhiza<\/jats:italic>(SM). Both SM and probucol feeding reduced plasma cholesterol. LDLs from the SM-treated group were more resistant to Cu<jats:sup>2+<\/jats:sup>-induced oxidation and contained more vitamin E (21.7\u00b12.1 nmol\/\u03bcmol LDL cholesterol) than did LDLs from the high cholesterol diet group (9.6\u00b11.8 nmol\/\u03bcmol LDL cholesterol) (<jats:italic>P<\/jats:italic>&lt;.005). Endothelial damage, determined at week 6, was reduced by 53% in the SM group (<jats:italic>P<\/jats:italic>&lt;.01). SM treatment reduced the atherosclerotic area in the abdominal aorta by 56% (<jats:italic>P<\/jats:italic>&lt;.005) and cholesterol deposition in the thoracic aorta by 50% (<jats:italic>P<\/jats:italic>&lt;.005). The severity of atherosclerosis in the SM group was significantly reduced after adjustment by using cholesterol exposure as an index of the cholesterol-lowering effect. This study concludes that the reduction of atherosclerosis by SM relies not only on its cholesterol-lowering effect but more heavily on its antioxidant potential to prevent endothelial damage and inhibit LDL oxidative modification in hypercholesterolemic animals.<\/jats:p>","DOI":"10.1161\/01.atv.18.3.481","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"481-486","source":"Crossref","is-referenced-by-count":130,"title":["Increase of Vitamin E Content in LDL and Reduction of Atherosclerosis in Cholesterol-Fed Rabbits by a Water-Soluble Antioxidant-Rich Fraction of<i>Salvia miltiorrhiza<\/i>"],"prefix":"10.1161","volume":"18","author":[{"given":"Yih-Jer","family":"Wu","sequence":"first","affiliation":[{"name":"From the Institutes of Traditional Medicine (Y.-J.W., C.-Y.H.) and Clinical Medicine (S.-J.L., C.-Y.H.), National Yang-Ming University; and the Departments of Medical Research and Education (M.-S.S.) and Internal Medicine (C.-Y.H., S.-J.L., P.W.), Veterans General Hospital, Taipei, Taiwan, ROC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Ye","family":"Hong","sequence":"additional","affiliation":[{"name":"From the Institutes of Traditional Medicine (Y.-J.W., C.-Y.H.) and Clinical Medicine (S.-J.L., C.-Y.H.), National Yang-Ming University; 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