{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:27:49Z","timestamp":1790857669627,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The hypothesis that stromelysin-3 (MMP-11), a unique member of the matrix metalloproteinase (MMP) family, plays a role in neointima formation was tested with the use of a vascular injury model in wild-type (MMP-11\n            <jats:sup>+\/+<\/jats:sup>\n            ) and MMP-11\u2013deficient (MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ) mice. Neointima formation 2 to 3 weeks after electric injury of the femoral artery was significantly enhanced in MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            as compared with MMP-11\n            <jats:sup>+\/+<\/jats:sup>\n            mice, in both mice of a pure 129SV genetic background (0.014 versus 0.0010 mm\n            <jats:sup>2<\/jats:sup>\n            at 2 weeks,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and those of a 50\/50 mixed 129SV\/BL6 background (0.030 versus 0.013 mm\n            <jats:sup>2<\/jats:sup>\n            at 3 weeks,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). The medial areas were comparable, resulting in intima\/media ratios that were significantly increased in MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            as compared with MMP-11\n            <jats:sup>+\/+<\/jats:sup>\n            arteries, in mice of both the 129SV (1.0 versus 0.18,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and mixed (1.5 versus 0.70,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) backgrounds. Nuclear cell counts in cross-sectional areas of the intima of the injured region were higher in arteries from MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice than in those from MMP-11\n            <jats:sup>+\/+<\/jats:sup>\n            mice (210 versus 48,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001, in pure 129SV mice and 290 versus 150,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01, in mice of the mixed genetic background). Immunocytochemical analysis revealed that \u03b1-actin\u2013positive and CD45-positive cells were more abundant in intimal sections of MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice. Degradation of the internal elastic lamina was more extensive in arteries of MMP-11\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice than in those of MMP-11\n            <jats:sup>+\/+<\/jats:sup>\n            mice (39% versus 6.8% at 3 weeks,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.005). The mechanisms by which MMP-11 could impair elastin degradation and cellular migration in this model remain, however, unknown.\n          <\/jats:p>","DOI":"10.1161\/01.atv.19.12.2863","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"2863-2870","source":"Crossref","is-referenced-by-count":46,"title":["Accelerated Neointima Formation After Vascular Injury in Mice With Stromelysin-3 (MMP-11) Gene Inactivation"],"prefix":"10.1161","volume":"19","author":[{"given":"H. Roger","family":"Lijnen","sequence":"first","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthe","family":"Van Hoef","sequence":"additional","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Vanlinthout","sequence":"additional","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Verstreken","sequence":"additional","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Rio","sequence":"additional","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u0301sire\u0301","family":"Collen","sequence":"additional","affiliation":[{"name":"From the Center for Molecular and Vascular Biology (H.R.L., B.V.H., I.V., M.V., D.C.), University of Leuven, Leuven, Belgium; and CNRS-INSERM-ULP (M.-C.R.), Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Libby P Schwartz D Brogi E Tanaka H Clinton SK. 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