{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:40:27Z","timestamp":1784425227992,"version":"3.55.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Mutations of the gene encoding tissue factor pathway inhibitor (TFPI), an inhibitor of TF-induced activation of the coagulation cascade, were screened for in 130 patients and 142 healthy controls to determine whether these variants contribute to acute coronary syndromes or modify plasma TFPI levels. The following 3 new polymorphisms were identified: 384T\u2192C in exon IV, which does not change the corresponding amino acid (tyrosine 57); \u221233C\u2192T in intron 7 (the T\/T, C\/T, and C\/C genotypes were found in \u224850%, 40%, and 10% of subjects in both groups); and 874G\u2192A in exon IX (GTG\u2192ATG), which predicts a valine to methionine change (V264M) in the carboxy-terminus tail of TFPI. The V264M polymorphism was found in 9.2% of the cases and 4.9% of the controls; the associated odds ratio (OR) for acute coronary syndromes was 2.0 (95% confidence interval [CI], 0.7 to 5.1). The OR increased to 3.6 (95% CI, 0.8 to 15.7) and 3.2 (95% CI, 0.9 to 11.8) in nonsmokers and patients without other risk factors, respectively. The possible link between the V264M polymorphism and coronary heart disease was checked in a large case-control study of myocardial infarction (Etude Cas-Te\u0301moins de l\u2019Infarctus du Myocarde [the ECTIM Study]). The results showed no link between the V264M polymorphism and coronary syndromes. Interestingly, however, 5 patients heterozygous for the V264M polymorphism had significantly lower plasma TFPI levels than did 13 patients with the most common genotype. Although our present results do not support an association between TFPI polymorphisms and acute coronary syndromes, the possibility that 1 of them, especially the exon IX polymorphism, is associated with subtypes of myocardial infarction or to evolutive particularities that were not assessed in this study, cannot be excluded and is currently being evaluated.\n          <\/jats:p>","DOI":"10.1161\/01.atv.19.4.862","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"862-869","source":"Crossref","is-referenced-by-count":42,"title":["Polymorphisms of the Tissue Factor Pathway Inhibitor (TFPI) Gene in Patients With Acute Coronary Syndromes and in Healthy Subjects"],"prefix":"10.1161","volume":"19","author":[{"given":"Didier","family":"Moatti","sequence":"first","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Seknadji","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Galand","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette","family":"Poirier","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Fumeron","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Desprez","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Garbarz","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dhermy","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Arveiler","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alun","family":"Evans","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Luc","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Bernard","family":"Ruidavets","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Ollivier","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Hakim","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Claude","family":"Aumont","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"de Prost","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d\u2019He\u0301matologie et d\u2019Immunologie (D.M., S.D., V.O., J.H., D.d.P.), Service de cardiologie A (P.S., M.C.A.), INSERM U409 (C.G., M.G., D.D.), Laboratoire de nutrition humaine, CHU Xavier Bichat (F.F.), and INSERM SC7 (O.P.), Paris, France; the MONICA Project, Bas-Rhin (D.A.), Lille (G.L.), and Haute-Garonne (J.-B.R.), France; and the MONICA Project, Belfast, Northern Ireland (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.4.7718033"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.1.1.1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.6.1226"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.4.7923650"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657572"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.103"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00220a018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1016\/S0021-9258(19)67752-5","volume":"266","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90134-A"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.6.1496.1496"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.2.2752565"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/359641a0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.12.6.1534257"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90084-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1016\/S0021-9258(18)68737-X","volume":"263","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.9.5759"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)55032-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.4.393"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656134"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199106000-00004"},{"key":"e_1_3_2_21_2","first-page":"547","volume":"69","year":"1998","journal-title":"Thromb Res"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3030923"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124400"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.16.6.802"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90233-E"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201303260506"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1182\/blood.V79.8.2004.2004","volume":"79","year":"1992","journal-title":"Blood"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","unstructured":"Novotny WF Palmier M Wun TC Broze GJ Miletich JP. 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