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In this study, LPS receptor CD14 was analyzed to find genetic variants and check them for an association with coronary artery disease or myocardial infarction (MI). When screening the CD14 gene by single-strand conformation polymorphism analysis, a promoter polymorphism was detected and confirmed as a T-to-C exchange at position \u2212159. We determined the genotypes of 2228 men who had undergone coronary angiography for diagnostic purposes. Within the total study group there was no significant association of either genotype with MI or coronary artery disease. However, in a subgroup with low coronary risk (normotensive nonsmokers), a relative risk for MI in probands homozygous for the T allele could be evaluated (OR, 1.6; 95% CI, 1.0 to 2.4;<jats:italic>P<\/jats:italic>&lt;0.05). The association was even stronger in low-risk patients older than 62 years (OR, 3.8; 95% CI, 1.6 to 9.0;<jats:italic>P<\/jats:italic>&lt;0.01). In conclusion, we describe a new CD14 promoter polymorphism that is associated with MI, especially in older patients with a low atherosclerotic risk profile.<\/jats:p>","DOI":"10.1161\/01.atv.19.4.932","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"932-938","source":"Crossref","is-referenced-by-count":117,"title":["A New Promoter Polymorphism in the Gene of Lipopolysaccharide Receptor CD14 Is Associated With Expired Myocardial Infarction in Patients With Low Atherosclerotic Risk Profile"],"prefix":"10.1161","volume":"19","author":[{"given":"Katja","family":"Unkelbach","sequence":"first","affiliation":[{"name":"From the Max-Planck-Institut fu\u0308r Physiologische und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim (K.U.); the Institut fu\u0308r Klinische Chemie und Pathobiochemie (A.G., M.P.), the Institut fu\u0308r Humangenetik (M.K.), and Zentrum fu\u0308r Innere Medizin, Abteilung Kardiologie und Angiologie (H.T., W.H.), Justus-Liebig-Universita\u0308t Giessen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gardemann","sequence":"additional","affiliation":[{"name":"From the Max-Planck-Institut fu\u0308r Physiologische und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim (K.U.); the Institut fu\u0308r Klinische Chemie und Pathobiochemie (A.G., M.P.), the Institut fu\u0308r Humangenetik (M.K.), and Zentrum fu\u0308r Innere Medizin, Abteilung Kardiologie und Angiologie (H.T., W.H.), Justus-Liebig-Universita\u0308t Giessen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kostrzewa","sequence":"additional","affiliation":[{"name":"From the Max-Planck-Institut fu\u0308r Physiologische und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim (K.U.); the Institut fu\u0308r Klinische Chemie und Pathobiochemie (A.G., M.P.), the Institut fu\u0308r Humangenetik (M.K.), and Zentrum fu\u0308r Innere Medizin, Abteilung Kardiologie und Angiologie (H.T., W.H.), Justus-Liebig-Universita\u0308t Giessen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Philipp","sequence":"additional","affiliation":[{"name":"From the Max-Planck-Institut fu\u0308r Physiologische und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim (K.U.); 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