{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T01:02:11Z","timestamp":1648947731593},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ATVB"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The present analysis was undertaken to study the effect of oral contraceptive (OC) use on activated factor VII (FVIIa) in subjects characterized by FVII genotypes, with the further aim of evaluating the role of lipids in this pharmacological interaction. In OC users (n=42) and nonusers (n=130) of comparable age, we examined the FVII phenotypic variables (FVII coagulant activity [FVIIc], FVII antigen, and FVIIa), FVII genotypes (the 353R\/Q and 5\u2032F7 polymorphisms analyzed in combination; alleles\n            <jats:italic>M1<\/jats:italic>\n            \/\n            <jats:italic>M2<\/jats:italic>\n            and\n            <jats:italic>A1<\/jats:italic>\n            \/\n            <jats:italic>A2<\/jats:italic>\n            , respectively), and a number of lipid and lipoprotein parameters: serum concentrations of total cholesterol (chol), low density lipoprotein and high density lipoprotein-chol, triglycerides, phospholipids (PhLs), apolipoprotein A1, and lipoprotein(a). PhLs, triglycerides, apolipoprotein A1, chol, FVII antigen, FVIIc, and high density lipoprotein-chol levels were shown to be statistically higher in users than nonusers. FVII levels, particularly those of FVIIa and FVIIc, were much higher in homozygotes for the\n            <jats:italic>A1<\/jats:italic>\n            and\n            <jats:italic>M1<\/jats:italic>\n            alleles (\n            <jats:italic>A11<\/jats:italic>\n            <jats:italic>M11<\/jats:italic>\n            ), especially in OC users. A strong association was found between PhL and FVIIa: in the multiple regression analysis, women taking OCs who had elevated PhL concentrations also had very high levels of FVIIa, but only if their genotype was\n            <jats:italic>A11 M11<\/jats:italic>\n            . These results indicate that the increased FVII levels in OC users depend on the FVII genotype and that high PhL concentrations predict very high levels of FVIIa and FVIIc.\n          <\/jats:p>","DOI":"10.1161\/01.atv.19.8.2024","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"2024-2028","source":"Crossref","is-referenced-by-count":2,"title":["Oral Contraceptives Highlight the Genotype-Specific Association Between Serum Phospholipids and Activated Factor VII"],"prefix":"10.1161","volume":"19","author":[{"given":"G.","family":"Mariani","sequence":"first","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Conard","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bernardi","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bertina","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Vicente","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Prydz","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Samama","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Sandset","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Puopolo","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"Ciarla","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Poso","sequence":"additional","affiliation":[{"name":"From the Hematology and Bone Marrow Transplantation Unit (G.M.), University Hospital, Palermo; the Department of Human Biopathology (G.D.D.N., M.V.C., F.C.), University of Rome \u201cLa Sapienza,\u201d Rome; and the Department of Biochemistry and Molecular Biology (F.B., G.M.), University of Ferrara, Ferrara, Italy; Leiden University Medical Center (R.B.), Leiden, the Netherlands; the Department of Hematology (V.V.G., R.P), Murcia University Hospital, Murcia, Spain; the Biotechnology Centre (H.P.), University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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Serum phospholipids are prominent determinants of factor VII levels in the most common FVII genotype. Haematologica. 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