{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:45:44Z","timestamp":1789706744971,"version":"4.0.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arteriosclerosis"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>The C apolipoproteins are normally transferred to high density lipoproteins (HDL) after lipolysis of very low density lipoprotein (VLDL) triglyceride. In previous studies, a loss of plasma C apolipoproteins was documented after heparin-induced lipolysis in hypertriglyceridemic subjects. The present studies were designed to determine if this decline in plasma C apolipoproteins was due to their clearance with VLDL remnants. Five Type IV hypertriglyceridemic and two normal subjects were injected with 125I-VLDL and 131I-low density lipoproteins (LDL) to document kinetically an excess of VLDL apolipoprotein (apo) B flux relative to LDL apo B flux in the Type IV subjects. A mean of 46% VLDL apo B was cleared from the circulation, without conversion to intermediate density lipoprotein (IDL) or LDL. Heparin was then infused (9000 IU over 4 hours) to generate an excess of VLDL remnants that were not converted to IDL or LDL. VLDL triglyceride, apo B, and apo C concentrations fell at a similar rate. VLDL apo B declined by 42% (p less than 0.01). However, no increases were observed in IDL or LDL apo B in the Type IV subjects. This resulted in a 14% (p less than 0.01) decline in plasma apo B concentrations, indicating a clearance of VLDL remnants. VLDL apo C-II and C-III concentrations fell by 42% (p less than 0.025) and 52% (p less than 0.01), respectively. During the first 2.5 hours of infusion, they were almost quantitatively recovered in HDL. Thereafter, the C apolipoproteins declined in HDL during which time VLDL apo C concentrations continued to decline.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1161\/01.atv.8.5.471","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:44:19Z","timestamp":1308339859000},"page":"471-479","source":"Crossref","is-referenced-by-count":22,"title":["Metabolism of apolipoproteins C-II, C-III, and B in hypertriglyceridemic men. Changes after heparin-induced lipolysis."],"prefix":"10.1161","volume":"8","author":[{"given":"M W","family":"Huff","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospital, University of Western Ontario, London, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Breckenridge","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, University of Western Ontario, London, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W L","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, University of Western Ontario, London, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, University of Western Ontario, London, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Arteriosclerosis: An Official Journal of the American Heart Association, Inc."],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.ATV.8.5.471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T18:50:04Z","timestamp":1715021404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.ATV.8.5.471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1161\/01.ATV.8.5.471"],"URL":"https:\/\/doi.org\/10.1161\/01.atv.8.5.471","relation":{},"ISSN":["0276-5047"],"issn-type":[{"value":"0276-5047","type":"print"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}