{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:48Z","timestamp":1762505928575},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1950,6]]},"abstract":"<jats:p>Congestive failure has been considered a relative contraindication to antisyphilitic therapy in cardiovascular syphilis since the arsphenamine era, when severe reactions were reported following administration of this vasculotoxic drug. After having observed no severe reactions to penicillin in a series of patients with cardiovascular syphilis, it was decided to administer the antibiotic as initial therapy for individuals in congestive failure. This report summarizes observations on twelve such patients. There were no severe reactions during the course of treatment in the entire group. Digitalis and other measures to restore compensation were used concomitantly with penicillin. All the patients were improved upon completion of therapy. Case histories of 2 patients who died two months after treatment, are given. The significance of observations on the entire group is discussed.<\/jats:p>","DOI":"10.1161\/01.cir.1.6.1355","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T23:15:32Z","timestamp":1339456532000},"page":"1355-1361","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Penicillin Treatment of Patients with Cardiovascular Syphilis in Congestive Failure"],"prefix":"10.1161","volume":"1","author":[{"given":"JOSEPH","family":"EDEIKEN","sequence":"first","affiliation":[{"name":"From the Institute for the Study of Venereal Disease, the Department of Dermatology and Syphilology and the Robinette Foundation of the University of Pennsylvania, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM T.","family":"FORD","sequence":"additional","affiliation":[{"name":"From the Institute for the Study of Venereal Disease, the Department of Dermatology and Syphilology and the Robinette Foundation of the University of Pennsylvania, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MORTIMER S.","family":"FALK","sequence":"additional","affiliation":[{"name":"From the Institute for the Study of Venereal Disease, the Department of Dermatology and Syphilology and the Robinette Foundation of the University of Pennsylvania, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN H.","family":"STOKES","sequence":"additional","affiliation":[{"name":"From the Institute for the Study of Venereal Disease, the Department of Dermatology and Syphilology and the Robinette Foundation of the University of Pennsylvania, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.1.6.1355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:05:30Z","timestamp":1715519130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.1.6.1355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1950,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1950,6]]}},"alternative-id":["10.1161\/01.CIR.1.6.1355"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.1.6.1355","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1950,6]]},"assertion":[{"value":"1950-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}