{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:40:54Z","timestamp":1761561654226},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,10,5]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Experimental studies have demonstrated that\n            <jats:sup>32<\/jats:sup>\n            P radioactive stents reduce neointimal formation at 28 days in porcine iliac and coronary arteries. Our objective was to determine the long-term dose-response effects of 1.0- to 12.0-\u03bcCi\n            <jats:sup>32<\/jats:sup>\n            P radioactive stents in a porcine atherosclerotic coronary model.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Control (n=19) and 1.0- to 12.0-\u03bcCi\n            <jats:sup>32<\/jats:sup>\n            P radioactive (n=43) stents (total, n=62) were implanted in the coronary arteries of 31 miniature swine at 28 days after creation of a fibrocellular plaque by overstretch balloon injury and cholesterol feeding. Angiography and histomorphometry were performed at 6 months. Stent thrombosis occurred in 3 radioactive (7.7%) and no control stents (\n            <jats:italic>P<\/jats:italic>\n            =0.54). On histology, the mean neointimal area and the percent in-stent stenosis correlated positively with increasing stent activity (\n            <jats:italic>r<\/jats:italic>\n            =0.64,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). The mean neointimal area (mm\n            <jats:sup>2<\/jats:sup>\n            ) for the stents with \u22653.0 \u03bcCi\n            <jats:sup>32<\/jats:sup>\n            P (3.57\u00b11.21) was significantly greater than that for the nonradioactive stents (1.78\u00b10.68,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). The neointima of the stents with \u22653.0 \u03bcCi\n            <jats:sup>32<\/jats:sup>\n            P was composed of smooth muscle cells, matrix proteoglycans, calcification, foam cells, and cholesterol clefts.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Continuous low-dose-rate irradiation delivered by high-activity\n            <jats:sup>32<\/jats:sup>\n            P radioactive stents promotes the formation of an \u201catheromatous\u201d neointima after 6 months in this experimental model. These data may be useful for predicting late tissue responses to radioactive stents in human coronary arteries.\n          <\/jats:p>","DOI":"10.1161\/01.cir.100.14.1548","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1548-1554","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Dose-Response Effects of\n            <sup>32<\/sup>\n            P Radioactive Stents in an Atherosclerotic Porcine Coronary Model"],"prefix":"10.1161","volume":"100","author":[{"given":"Andrew J.","family":"Carter","sequence":"first","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Scott","sequence":"additional","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Bailey","sequence":"additional","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Hoopes","sequence":"additional","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russ","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"From the Cardiology Research Foundation, Washington Hospital Center (A.J.C., D.S., L.B.), Walter Reed Army Medical Center (T.H.), and the Armed Forces Institute of Pathology (R.J., R.V.), Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2956"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1570"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.3.529"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2364"},{"key":"e_1_3_2_5_2","first-page":"641","volume":"93","year":"1995","unstructured":"Hehrlein C, Stintz M, Kinscherf R, Schlosser K, Huttel E, Friedrich L, Fehsenfeld P, Kubler W. 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