{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:40:54Z","timestamp":1761561654655},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,10,19]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014This study represents the Heart Center Rotterdam\u2019s contribution to the Isostents for Restenosis Intervention Study, a nonrandomized multicenter trial evaluating the safety and feasibility of the radioactive Isostent in patients with single coronary artery disease. Restenosis after stent implantation is primarily caused by neointimal hyperplasia. In animal studies, \u03b2-particle\u2013emitting radioactive stents decrease neointimal hyperplasia by inhibiting smooth muscle cell proliferation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014The radioisotope\n            <jats:sup>32<\/jats:sup>\n            P, a \u03b2-particle emitter with a half-life of 14.3 days, was directly embedded into the Isostent. The calculated range of radioactivity was 0.75 to 1.5 \u03bcCi. Quantitative coronary angiography measurements were performed before and after the procedure and at 6-month follow-up. A total of 31 radioactive stents were used in 26 patients; 30 (97%) were successfully implanted, and 1 was embolized. Treated lesions were in the left anterior descending coronary artery (n=12), the right coronary artery (n=8), or the left circumflex coronary artery (n=6). Five patients received additional, nonradioactive stents. Treated lesion lengths were 13\u00b14 mm, with a reference diameter of 2.93\u00b10.47 mm. Minimum lumen diameter increased from 0.87\u00b10.28 mm preprocedure to 2.84\u00b10.35 mm postprocedure. No in-hospital adverse cardiac events occurred. All patients received aspirin indefinitely and ticlopidine for 4 weeks. Twenty-three patients (88%) returned for 6-month angiographic follow-up; 17% of them had in-stent restenosis, and 13% had repeat revascularization. No restenosis was observed at the stent edges. Minimum lumen diameter at follow-up averaged 1.85\u00b10.69 mm, which resulted in a late loss of 0.99\u00b10.59 mm and a late loss index of 0.53\u00b10.35. No other major cardiac events occurred during the 6-month follow-up.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014The use of radioactive stents with an activity of 0.75 to 1.5 \u03bcCi is safe and feasible.\n          <\/jats:p>","DOI":"10.1161\/01.cir.100.16.1684","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1684-1689","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["\u03b2-Particle\u2013Emitting Radioactive Stent Implantation"],"prefix":"10.1161","volume":"100","author":[{"given":"A. J.","family":"Wardeh","sequence":"first","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. P.","family":"Kay","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sabate\u0301","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. L. M. A.","family":"Coen","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Gijzel","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. R.","family":"Ligthart","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"den Boer","sequence":"additional","affiliation":[{"name":"From the Thoraxcenter, Heartcenter, University Hospital Rotterdam, Dijkzigt (A.J.W., I.P.K., M.S., A.L.G., J.M.R.L., A.d.B., W.J.v.d.G., P.W.S.), and the Daniel den Hoed, Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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