{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:47:31Z","timestamp":1762098451436},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,11,9]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The currently used American College of Cardiology\/American Heart Association lesion classification scheme dates from an era when balloon angioplasty was the only percutaneous treatment available and major complications occurred in \u22487% of patients. Major advances in treatment options would suggest that this scheme may be outmoded, but the schemes that have been suggested to update lesion classification have not been widely accepted.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Four thousand one hundred eighty-one consecutive patients (6676 lesions) formed a training set and 2146 patients (4231 lesions) formed a validation set treated from 1995 to 1997 at a single center used by 3 hospital groups. Twenty-seven pretreatment candidate variables were analyzed with the use of stepwise proportional logistic regression, and 9 (nonchronic total occlusion with TIMI flow 0, degenerated vein graft, vein graft age &gt;10 years, lesion length \u226510 mm, severe calcium, lesion irregularity, large filling defect, angulated \u226545 degrees plus calcium, and eccentricity) were independently correlated (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) with ranked adverse outcome (death, Q-wave or creatine kinase \u22653\u00d7 normal myocardial infarction, or emergency coronary artery bypass grafting\u226bcreatine kinase 2 to 3\u00d7 myocardial infarction\u226bpossibly related to non\u2013Q-wave myocardial infarction\u226bno complication). A scheme based on these findings and the old American College of Cardiology\/American Heart Association scheme were found to have c-statistics in the validation set of 0.672 and 0.620 (\n            <jats:italic>P<\/jats:italic>\n            =0.010 vs old scheme), respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Appreciation of these contemporary risk factors for complications of coronary intervention may assist in patient selection and in risk adjustment for comparison of outcomes between providers.\n          <\/jats:p>","DOI":"10.1161\/01.cir.100.19.1971","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1971-1976","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Relation Between Lesion Characteristics and Risk With Percutaneous Intervention in the Stent and Glycoprotein IIb\/IIIa Era"],"prefix":"10.1161","volume":"100","author":[{"given":"Stephen G.","family":"Ellis","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (S.G.E., V.G., P.L.W., E.J.T.) and Biostatistics (D.M.), The Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Guetta","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.G.E., V.G., P.L.W., E.J.T.) and Biostatistics (D.M.), The Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Miller","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.G.E., V.G., P.L.W., E.J.T.) and Biostatistics (D.M.), The Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick L.","family":"Whitlow","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.G.E., V.G., P.L.W., E.J.T.) and Biostatistics (D.M.), The Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Topol","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (S.G.E., V.G., P.L.W., E.J.T.) and Biostatistics (D.M.), The Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90431-7"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.82.4.2401060"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.1.8281682"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.1.91"},{"key":"e_1_3_2_5_2","first-page":"37","volume":"31","year":"1997","unstructured":"Park S-J, Park S-W, Hong M-K, Cheong S-S, Lee CW, Kim J-J, Hong MK, Mintz GS Leon MB. 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