{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:02:30Z","timestamp":1785200550125,"version":"3.55.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,11,30]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte chemotactic protein-1 (MCP-1) expression were studied in cholesterol-fed rabbits.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Male rabbits were fed a 2% cholesterol diet together with red wine (12.5% vol, 5 mL\/kg body wt per day; n=7), white wine (13.3% vol, 5 mL\/kg body wt per day; n=7), or no wine as a control (n=8) for 6 weeks. A balloon injury of the abdominal aorta was performed at the end of the third week. Abdominal aortas were harvested at the end of 6 weeks. Neointimal hyperplasia was measured morphometrically. MCP-1 expression was determined by Northern blot, in situ hybridization, and immunohistochemistry. Rabbits fed red wine had significantly less neointimal hyperplasia than did control rabbits (intima\/media area ratio 0.59\u00b10.05 [red wine group] versus 0.79\u00b10.07 [control group],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). However, rabbits fed white wine showed a trend (but not significant) toward less intimal response compared with control rabbits (intima\/media area ratio 0.65\u00b10.04 [white wine group] versus 0.79\u00b10.07 [control group],\n            <jats:italic>P<\/jats:italic>\n            =0.165). Both red wine and white wine significantly reduced MCP-1 mRNA and protein expression in the aorta.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Long-term consumption of red wine and white wine inhibits MCP-1 expression, and in the small number of animals studied, red wine modestly reduces neointimal hyperplasia. Since red wine exhibits higher antioxidant capacity than does white wine, the decreased intimal response might be partly attributed to its antioxidant effects.\n          <\/jats:p>","DOI":"10.1161\/01.cir.100.22.2254","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2254-2259","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Red Wine Inhibits Monocyte Chemotactic Protein-1 Expression and Modestly Reduces Neointimal Hyperplasia After Balloon Injury in Cholesterol-Fed Rabbits"],"prefix":"10.1161","volume":"100","author":[{"given":"An-Ning","family":"Feng","sequence":"first","affiliation":[{"name":"From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Lien","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw-Zon","family":"Ding","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing-Jong","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90542-W"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91277-F"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312163292501"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440220083011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505113321901"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198808043190503"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-11-967"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114418"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.6.727"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.4.1182"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.3.549"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90206-V"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90460-T"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.1.32"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90120-A"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404073301407"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370608"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.79.6.2524293"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370607"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.23.11312"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116326"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05423-G"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(96)05959-X"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.7.2295"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199707000-00004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5252"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5350"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118661"},{"key":"e_1_3_2_30_2","first-page":"101","volume":"88","year":"1995","unstructured":"Sharpe PC, McGrath LT, McClean E, Young IS, Archbold GPR. 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