{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:09Z","timestamp":1787017989248,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,12,14]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014The long-QT syndrome is associated with sudden cardiac death. Combination of \u03b2-blocker and pacing therapy has been proposed for treatment of drug-resistant patients. The purpose of this study was to summarize our long-term experience with combined therapy in patients with long-QT syndrome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results<\/jats:italic>\n                    \u2014A total of 37 patients with idiopathic long-QT syndrome were treated with combined therapy consisting of continuous cardiac pacing and maximally tolerated \u03b2-blocker therapy and followed up for 6.3\u00b14.6 years (mean\u00b1SD). The group consisted of 32 female and 5 male patients with a mean age of 31.6 years. The mean paced rate was 82\u00b17 bpm (range, 60 to 100 bpm). On follow-up, recurrent symptoms caused by pacemaker malfunction were documented in 3 patients. Four patients died during the follow-up period: 2 adolescents stopped \u03b2-blocker therapy, 1 patient died suddenly while treated with combined therapy, and 1 patient died of unrelated causes. In addition, 3 patients had resuscitated cardiac arrest while on combined therapy, and 1 patient had repeated, appropriate implantable cardioverter-defibrillator discharges on follow-up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Because 28 of 37 patients remain without symptoms with \u03b2-blocker therapy and continuous pacing, combined therapy appears to provide reasonable, long-term control for this high-risk group. However, the incidence of sudden death and aborted sudden death (24% in all patients and 17% in compliant patients) strongly suggests the use of a \u201cback-up\u201d defibrillator, particularly in noncompliant adolescent patients. Implantable cardioverter-defibrillator therapy, however, may be associated with recurrent shocks in susceptible patients.\n                  <\/jats:p>","DOI":"10.1161\/01.cir.100.24.2431","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T20:42:29Z","timestamp":1339447349000},"page":"2431-2436","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":117,"title":["Long-Term Follow-Up of Patients With Long-QT Syndrome Treated With \u03b2-Blockers and Continuous Pacing"],"prefix":"10.1161","volume":"100","author":[{"given":"Parvin C.","family":"Dorostkar","sequence":"first","affiliation":[{"name":"From the Divisions of Electrophysiology and Pediatric Cardiology, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eldar","sequence":"additional","affiliation":[{"name":"From the Divisions of Electrophysiology and Pediatric Cardiology, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Belhassen","sequence":"additional","affiliation":[{"name":"From the Divisions of Electrophysiology and Pediatric Cardiology, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin M.","family":"Scheinman","sequence":"additional","affiliation":[{"name":"From the Divisions of Electrophysiology and Pediatric Cardiology, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(88)90014-X"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1136"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.4.1914094"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00765.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03029822"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271204"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.8.1408"},{"key":"e_1_3_1_8_2","unstructured":"Moss AJ Robinson J. Clinical features of the idiopathic long-QT syndrome. Circulation. 1992;85(suppl I):I-140\u2013I-144."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90293-8"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1673802"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1094-141"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90358-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90359-3"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90340-2"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199601000-00008"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199601000-00001"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.1.142"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330613"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90626-X"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.2.1860195"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80203-6"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90180-U"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00403-3"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90103-1"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.6.2038"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.100.24.2431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T09:19:19Z","timestamp":1715505559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.100.24.2431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12,14]]},"references-count":25,"journal-issue":{"issue":"24","published-print":{"date-parts":[[1999,12,14]]}},"alternative-id":["10.1161\/01.CIR.100.24.2431"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.100.24.2431","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12,14]]},"assertion":[{"value":"1999-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}