{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:14:50Z","timestamp":1783491290418,"version":"3.55.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,7,20]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The mechanisms leading to dobutamine-induced ischemia are not fully understood. In the present study, we investigated the effects of high-dose intravenous dobutamine on morphological and physiological indexes of coronary stenoses.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Twenty-two patients with normal left ventricular function and isolated coronary stenoses were studied. At catheterization, mean aortic pressure (P\n            <jats:sub>a<\/jats:sub>\n            ), mean distal coronary pressure (P\n            <jats:sub>d<\/jats:sub>\n            ), and P\n            <jats:sub>d<\/jats:sub>\n            \/P\n            <jats:sub>a<\/jats:sub>\n            as an index of myocardial resistance were recorded at rest, after intracoronary adenosine, and during intravenous infusion of dobutamine (10 to 40 \u03bcg \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            ). Reference vessel diameter and minimal luminal diameter, as assessed by coronary angiography, did not change during dobutamine infusion compared with baseline (2.84\u00b10.49 versus 2.77\u00b10.41 mm and 1.35\u00b10.38 versus 1.27\u00b10.31 mm, respectively; both\n            <jats:italic>P<\/jats:italic>\n            =NS). During peak dobutamine infusion, P\n            <jats:sub>d<\/jats:sub>\n            and P\n            <jats:sub>d<\/jats:sub>\n            \/P\n            <jats:sub>a<\/jats:sub>\n            reached similar levels as during adenosine infusion (60\u00b118 versus 59\u00b118 mm Hg and 0.68\u00b10.18 versus 0.68\u00b10.17, respectively; all\n            <jats:italic>P<\/jats:italic>\n            =NS). In 9 patients, an additional bolus of intracoronary adenosine given at the peak dose of dobutamine failed to further decrease P\n            <jats:sub>d<\/jats:sub>\n            \/P\n            <jats:sub>a<\/jats:sub>\n            . Furthermore, in patients with dobutamine-induced wall motion abnormalities, the maximal decrease in P\n            <jats:sub>d<\/jats:sub>\n            \/P\n            <jats:sub>a<\/jats:sub>\n            was similar during dobutamine and adenosine infusions.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014High-dose intravenous infusion of dobutamine does not modify the dimensions of the epicardial coronary stenosis. However, much like the direct coronary vasodilator adenosine, dobutamine fully exhausts myocardial resistance regardless of the presence of mechanical dysfunction.\n          <\/jats:p>","DOI":"10.1161\/01.cir.100.3.243","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"243-249","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Effects of Dobutamine on Coronary Stenosis Physiology and Morphology"],"prefix":"10.1161","volume":"100","author":[{"given":"Jozef","family":"Bartunek","sequence":"first","affiliation":[{"name":"From the Cardiovascular Center, Aalst, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Aalst, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy R.","family":"Heyndrickx","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Aalst, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"de Bruyne","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center, Aalst, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107673"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.41.3.890890"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.53.5.1260986"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.45.6.498443"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00319-3"},{"key":"e_1_3_2_6_2","first-page":"1489","volume":"27","year":"1996","unstructured":"Bartunek J, Marwick TH, Vincent M, Rodrigues CT, Van Schuerbeeck E, Sys SU, De Bruyne B. 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