{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:58:05Z","timestamp":1761541085062,"version":"3.40.3"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[1999,8,24]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>\u2014Brief antecedent periods of coronary artery occlusion improve subsequent vessel patency in damaged and stenotic coronary arteries via release of adenosine from ischemic\/reperfused myocardium and resultant adenosine receptor stimulation. However, the site of receptor stimulation\u2014circulating blood-borne elements (ie, platelets) versus vessel-wall components of the culprit artery\u2014remains unclear. If platelet adenosine receptors are involved, then the benefits of brief coronary occlusion (1) should be manifested systemically and improve patency at a remote site and (2) should be inhibited by an antagonist of adenosine A<jats:sub>2<\/jats:sub>receptors, whereas, in contrast, (3) brief vascular occlusion not associated with appreciable adenosine release should be ineffective in improving vessel patency.<\/jats:p><jats:p><jats:italic>Methods and Results<\/jats:italic>\u2014In Protocol 1, anesthetized rabbits received 5 minutes of transient coronary occlusion, 5 minutes of transient bilateral carotid occlusion (purported to cause negligible adenosine release from the brain), or no intervention. All rabbits then underwent injury plus stenosis of the left carotid artery, resulting in repeated cyclic variations in carotid blood flow (CFVs). Carotid patency during the initial 2 hours after stenosis (assessed by quantifying the nadir of the CFVs and area of the flow-time profile) was significantly enhanced with antecedent coronary\u2014but not carotid\u2014occlusion versus controls. In Protocol 2, improvement in carotid patency after brief coronary occlusion was corroborated in anesthetized dogs. However, the benefits of brief coronary occlusion were abrogated by the A<jats:sub>2<\/jats:sub>\/A<jats:sub>1<\/jats:sub>antagonist CGS 15943.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>\u2014Brief antecedent coronary artery occlusion enhanced vessel patency in remote, damaged, and stenotic carotid arteries, largely due to adenosine receptor stimulation on circulating elements.<\/jats:p>","DOI":"10.1161\/01.cir.100.8.843","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"843-848","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Brief Myocardial Ischemia Attenuates Platelet Thrombosis in Remote, Damaged, and Stenotic Carotid Arteries"],"prefix":"10.1161","volume":"100","author":[{"given":"Katsuya","family":"Hata","sequence":"first","affiliation":[{"name":"From the Heart Institute, Good Samaritan Hospital and Department of Medicine (Section of Cardiology), University of Southern California, Los Angeles, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Whittaker","sequence":"additional","affiliation":[{"name":"From the Heart Institute, Good Samaritan Hospital and Department of Medicine (Section of Cardiology), University of Southern California, Los Angeles, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Kloner","sequence":"additional","affiliation":[{"name":"From the Heart Institute, Good Samaritan Hospital and Department of Medicine (Section of Cardiology), University of Southern California, Los Angeles, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Przyklenk","sequence":"additional","affiliation":[{"name":"From the Heart Institute, Good Samaritan Hospital and Department of Medicine (Section of Cardiology), University of Southern California, Los Angeles, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.1124"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.7.692"},{"key":"e_1_3_2_3_2","first-page":"H1460","volume":"269","year":"1995","unstructured":"Lasley RD, Konyn PJ, Hegge JO, Mentzer JM Jr. Effects of ischemia and adenosine preconditioning on interstitial fluid adenosine and myocardial infarct size. 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