{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:37:10Z","timestamp":1793900230018,"version":"4.8.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,3,28]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014To minimize acute stent thrombosis and development of restenosis, stents coated with biodegradable and nonbiodegradable polymers have been proposed to serve as sustained-release drug carriers.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In both a sheep and a pig model, we examined the vascular response to standard and high-pressure implantation of coronary Palmaz-Schatz stents coated with a 10-\u03bcm layer of polylactic acid (MW 30 kDa) releasing recombinant polyethylene glycol (r-PEG)\u2013hirudin and the prostacyclin analogue iloprost, both drugs with antithrombotic and potentially antiproliferative effects. Study observation time was 28 days. Between the corresponding stent groups, no differences were observed with regard to preplacement and postplacement implantation parameters. The morphometric analysis demonstrated that the coating was associated with a greater lumen diameter through a reduction in the mean restenosis area by 22.9% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02) in the standard-pressure model (sheep) and by 24.8% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02) in the overstretch pig model compared with uncoated control stents without inducing a local inflammatory response.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014The results from this study demonstrate beneficial effects of a polymeric stent coating with polylactic acid releasing r-PEG\u2013hirudin and iloprost on the development of restenosis after coronary stent placement at 4 weeks, independent of the extent of vascular injury. Future studies are proposed to investigate the integration of other substances to further enhance the potential of the stent coating on reducing neointimal formation.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.12.1453","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1453-1458","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Inhibition of Neointima Formation After Experimental Coronary Artery Stenting"],"prefix":"10.1161","volume":"101","author":[{"given":"Eckhard","family":"Alt","sequence":"first","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Haehnel","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Beilharz","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Prietzel","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Preter","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Stemberger","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Fliedner","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf","family":"Erhardt","sequence":"additional","affiliation":[{"name":"From the I. Medizinische Klinik and Deutsches Herzzentrum (E.A., I.H., C.B., K.P., D.P., T.F., A.S.) and the Department of Experimental Surgery (A.S., W.E.), Klinikum rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Scho\u0308mig","sequence":"additional","affiliation":[{"name":"From the I. 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