{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:00:37Z","timestamp":1778756437086,"version":"3.51.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,4,25]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Intracoronary \u03b3-radiation therapy reduces recurrent in-stent restenosis (ISR). This study, BETA WRIST (Washington Radiation for In-Stent restenosis Trial) was designed to examine the efficacy and safety of the \u03b2-emitter 90-yttrium for the prevention of recurrent ISR.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014A total of 50 consecutive patients with ISR in native coronaries underwent percutaneous transluminal coronary angioplasty, laser angioplasty, rotational atherectomy, and\/or stent implantation. Afterward, a segmented balloon catheter was positioned and automatically loaded with a 90-yttrium, 0.014-inch source wire that was 29 mm in length to deliver a dose of 20.6 Gy at 1.0 mm from the balloon surface. In 17 patients, manual stepping of the radiation catheter was necessary for lesions &gt;25 mm in length. The radiation was delivered successfully to all patients, with a mean dwell time of 3.0\u00b10.4 minutes. Fractionation of the dose due to ischemia was required in 11 patients. At 6 months, the binary angiographic restenosis rate was 22%, the target lesion revascularization rate was 26%, and the target vessel revascularization rate was 34%; all rates were significantly lower than those of the placebo group of \u03b3-WRIST.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014\u03b2-Radiation with a 90-yttrium source used as adjunct therapy for patients with ISR results in a lower-than-expected rate of angiographic and clinical restenosis.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.16.1895","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"1895-1898","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":230,"title":["Intracoronary \u03b2-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis"],"prefix":"10.1161","volume":"101","author":[{"given":"Ron","family":"Waksman","sequence":"first","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balram","family":"Bhargava","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"White","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna C.","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowell F.","family":"Satler","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto D.","family":"Pichard","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K.","family":"Kent","sequence":"additional","affiliation":[{"name":"From the Vascular Brachytherapy Institute, Washington Hospital Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90813-R"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00382-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.7.2183"},{"key":"e_1_3_2_4_2","first-page":"1697","volume":"335","year":"1996","unstructured":"Teirstein PS, Massullo V, Jani S, et al. Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Engl J Med. 1996;335:1697\u20131703.","journal-title":"N Engl J Med"},{"key":"e_1_3_2_5_2","unstructured":"Waksman R White RL Chan RC et al. Intracoronary gamma radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation. In press."},{"key":"e_1_3_2_6_2","first-page":"56A","volume":"33","year":"1999","unstructured":"Leon MB, Teirstein PS, Lansky AJ, et al. Intracoronary gamma radiation to reduce in-stent restenosis: the multicenter GAMMA1 randomized clinical trial. J Am Coll Cardiol. 1999;33:56A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.10.3025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2284"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.20.2025"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.5.1138"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.98.19.2024"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.8.780"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.CIR.101.16.1895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T13:01:30Z","timestamp":1715518890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.101.16.1895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4,25]]},"references-count":12,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2000,4,25]]}},"alternative-id":["10.1161\/01.CIR.101.16.1895"],"URL":"https:\/\/doi.org\/10.1161\/01.cir.101.16.1895","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4,25]]},"assertion":[{"value":"1999-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}