{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:57:39Z","timestamp":1793692659653,"version":"4.5.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,5,9]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Vascular nitric oxide (NO) bioavailability is reduced in patients with coronary artery disease (CAD). We investigated whether oral\n            <jats:sc>l<\/jats:sc>\n            -arginine, the substrate for NO synthesis, improves homeostatic functions of the vascular endothelium in patients maintained on appropriate medical therapy and thus might be useful as adjunctive therapy.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014Thirty CAD patients (29 men; age, 67\u00b18 years) on appropriate medical management were randomly assigned to\n            <jats:sc>l<\/jats:sc>\n            -arginine (9 g) or placebo daily for 1 month, with crossover to the alternate therapy after 1 month off therapy, in a double-blind study. Nitrogen oxides in serum (as an index of endothelial NO release), flow-mediated brachial artery dilation (as an index of vascular NO bioactivity), and serum cell adhesion molecules (as an index of NO-regulated markers of inflammation) were measured at the end of each treatment period.\n            <jats:sc>l<\/jats:sc>\n            -Arginine significantly increased arginine levels in plasma (130\u00b153 versus 70\u00b117 \u03bcmol\/L,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) compared with placebo. However, there was no effect of\n            <jats:sc>l<\/jats:sc>\n            -arginine on nitrogen oxides (19.3\u00b17.9 versus 18.6\u00b16.7 \u03bcmol\/L,\n            <jats:italic>P<\/jats:italic>\n            =0.546), on flow-mediated dilation of the brachial artery (11.9\u00b16.3% versus 11.4\u00b17.9%,\n            <jats:italic>P<\/jats:italic>\n            =0.742), or on the cell adhesion molecules E-selectin (47.8\u00b115.2 versus 47.2\u00b114.4 ng\/mL,\n            <jats:italic>P<\/jats:italic>\n            =0.601), intercellular adhesion molecule-1 (250\u00b157 versus 249\u00b157 ng\/mL,\n            <jats:italic>P<\/jats:italic>\n            =0.862), and vascular cell adhesion molecule-1 (567\u00b1124 versus 574\u00b1135 ng\/mL,\n            <jats:italic>P<\/jats:italic>\n            =0.473).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Oral\n            <jats:sc>l<\/jats:sc>\n            -arginine therapy does not improve NO bioavailability in CAD patients on appropriate medical management and thus may not benefit this group of patients.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.18.2160","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2160-2164","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":130,"title":["Oral\n            <scp>l<\/scp>\n            -Arginine in Patients With Coronary Artery Disease on Medical Management"],"prefix":"10.1161","volume":"101","author":[{"given":"Arnon","family":"Blum","sequence":"first","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Londa","family":"Hathaway","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Mincemoyer","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Schenke","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Kirby","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Csako","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron A.","family":"Waclawiw","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio A.","family":"Panza","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Richard O.","family":"Cannon","sequence":"additional","affiliation":[{"name":"From the Cardiology (A.B., L.H., R.M., W.H.S., J.A.P., R.O.C.) and Hematology (M.K.) Branches and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute; and the Clinical Pathology Department (G.C.), Clinical Center, National Institutes of Health, Bethesda, Md."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610233151702"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.81.2.2105174"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.2.1991363"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116183"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117852"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/333664a0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90760-V"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.2.130"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00279-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61692-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00563-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.5.1314"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118632"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.21.2123"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.21.2829"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00354-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf60201a034"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118074"},{"key":"e_1_3_2_19_2","unstructured":"Shapiro HM. 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