{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:32:04Z","timestamp":1791318724995,"version":"4.3.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,5,23]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014The continuous infusion of prostacyclin has been shown to improve exercise capacity and survival in patients with primary pulmonary hypertension (PPH). Inhalation of iloprost, a stable analog of prostacyclin, might be an alternative therapy for PPH, selectively acting on the pulmonary vascular bed through ventilation-matched alveolar deposition of the drug. We investigated the short-term effects of iloprost inhalation on exercise capacity and gas exchange in patients with PPH.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014In 11 patients with PPH, we performed 2 consecutive cardiopulmonary exercise tests before and after the inhalation of 17 \u03bcg of iloprost. Patients had marked pulmonary hypertension (mean pulmonary artery pressure 65 mm Hg), and inhalation resulted in a decrease in pulmonary vascular resistance (1509 versus 1175 dyne \u00b7 s\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 cm\n            <jats:sup>\u22125<\/jats:sup>\n            ,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Arterial blood gases remained unchanged (Pa\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            69.3 versus 66.8 mm Hg; Pa\n            <jats:sc>co<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            29.6 versus 28.8 mm Hg). Iloprost significantly (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) improved exercise duration (379 versus 438 seconds), peak oxygen uptake (12.8 versus 14.2 mL \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            ), and V\u0307\n            <jats:sc>e<\/jats:sc>\n            -versus-V\u0307\n            <jats:sc>co<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            slope (58 versus 51.4).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014The present data show that iloprost inhalation exerts pulmonary vasodilatation and improves symptoms and exercise capacity in patients with PPH. The data also suggest that iloprost inhalation is a suitable treatment for PPH. Whether these effects are maintained during long-term treatment and are paralleled by improvement in prognosis remains to be determined.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.20.2388","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2388-2392","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Effects of Iloprost Inhalation on Exercise Capacity and Ventilatory Efficiency in Patients With Primary Pulmonary Hypertension"],"prefix":"10.1161","volume":"101","author":[{"given":"Roland","family":"Wensel","sequence":"first","affiliation":[{"name":"From Humboldt University Berlin (C.F.O., L.B., F.X.K.) and Deutsches Herzzentrum Berlin (R.W., R.E.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Opitz","sequence":"additional","affiliation":[{"name":"From Humboldt University Berlin (C.F.O., L.B., F.X.K.) and Deutsches Herzzentrum Berlin (R.W., R.E.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ewert","sequence":"additional","affiliation":[{"name":"From Humboldt University Berlin (C.F.O., L.B., F.X.K.) and Deutsches Herzzentrum Berlin (R.W., R.E.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"Bruch","sequence":"additional","affiliation":[{"name":"From Humboldt University Berlin (C.F.O., L.B., F.X.K.) and Deutsches Herzzentrum Berlin (R.W., R.E.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Kleber","sequence":"additional","affiliation":[{"name":"From Humboldt University Berlin (C.F.O., L.B., F.X.K.) and Deutsches Herzzentrum Berlin (R.W., R.E.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90279-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.1.236"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.5.2805259"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.5.2805258"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270203"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198206033062203"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80048-0"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.3.270"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340504"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380501"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199604000-00019"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92004-D"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015478"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-9-199605010-00006"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.6.1213"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.6.1662"},{"key":"e_1_3_1_19_2","unstructured":"Wasserman K Stringer WW Casaburi R et al. 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