{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T22:55:30Z","timestamp":1717368930873},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2000,5,30]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Previous studies have shown that repeated systemic administration of human recombinant hepatocyte growth factor (hrHGF) in mg\/kg levels modulates the wound-healing process in various diseases. Recently, HGF has been characterized as one of the most potent endothelial-cell\u2013specific growth factors. We tested our hypothesis that local delivery of hrHGF, even at low \u03bcg\/kg levels (\u22652 orders of magnitude lower than systemically administered doses), might attenuate neointimal hyperplasia in response to vascular injury via accelerated reendothelialization.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods and Results<\/jats:italic>\n            \u2014The iliac artery was denuded in 16 New Zealand White rabbits (3 kg), followed by administration, via a drug delivery catheter, of either hrHGF (10 \u03bcg; n=11) or control vehicle (n=5) over 20 minutes. In pilot studies using this device, the drug permeated into the medial tissues, where it persisted for \u226524 hours. Four weeks after the local delivery of hrHGF, computer-assisted morphometric analysis revealed significant reduction in the intimal area (hrHGF, 0.37\u00b10.21 versus control, 0.68\u00b10.16 mm\n            <jats:sup>2<\/jats:sup>\n            , mean\u00b1SD;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) but no change in the medial area (hrHGF, 1.03\u00b10.21 versus control, 1.10\u00b10.52 mm\n            <jats:sup>2<\/jats:sup>\n            ). Scanning electron microscopy revealed extensive endothelialization with regular and confluent endothelial cell layer regeneration in the hrHGF-treated vessels.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Accelerated endothelialization after local delivery of hrHGF, a novel and potent endothelial cell mitogen, effectively attenuates neointimal proliferation even after single low-dose administration. This observation could have potential therapeutic implications in the prevention of restenosis after angioplasty.\n          <\/jats:p>","DOI":"10.1161\/01.cir.101.21.2546","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:42:29Z","timestamp":1339461749000},"page":"2546-2549","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Single Low-Dose Administration of Human Recombinant Hepatocyte Growth Factor Attenuates Intimal Hyperplasia in a Balloon-Injured Rabbit Iliac Artery Model"],"prefix":"10.1161","volume":"101","author":[{"given":"Satoshi","family":"Yasuda","sequence":"first","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Noguchi","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Gohda","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Arai","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobumasa","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nonogi","sequence":"additional","affiliation":[{"name":"From the National Cardiovascular Center, Osaka (S.Y., T.N., M.G., T.M., H.N.), and Tokai Medical Products Inc, Aichi (T.A., N.T.), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884465"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(97)80003-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.11.2793"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.2.308"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.4.7923695"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7517"},{"key":"e_1_3_2_7_2","first-page":"81","volume":"26","year":"1997","unstructured":"Matsuda Y, Matsumoto K, Yamada A, Ichida T, Asakura H, Komoriya Y, Nishiyama E, Nakamura T. 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